Bruce L Homer
Overview
Explore the profile of Bruce L Homer including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
256
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0
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Recent Articles
1.
Winkler A, Sun W, De S, Jiao A, Sharif M, Symanowicz P, et al.
Arthritis Rheumatol
. 2021 Aug;
73(12):2206-2218.
PMID: 34423919
Objective: To investigate the role of PF-06650833, a highly potent and selective small-molecule inhibitor of interleukin-1-associated kinase 4 (IRAK4), in autoimmune pathophysiology in vitro, in vivo, and in the clinical...
2.
Homer B, Dower K
Toxicol Pathol
. 2018 Oct;
46(8):976-977.
PMID: 30278832
This symposium synopsis summarizes key results from a 41-week study of diabetic nephropathy (DN) in the type 2 diabetic ZSF1 fa/fa rat model. During this study, we conducted longitudinal analysis...
3.
Dower K, Zhao S, Schlerman F, Savary L, Campanholle G, Johnson B, et al.
PLoS One
. 2017 Jul;
12(7):e0181861.
PMID: 28746409
ZSF1 rats exhibit spontaneous nephropathy secondary to obesity, hypertension, and diabetes, and have gained interest as a model system with potentially high translational value to progressive human disease. To thoroughly...
4.
Nassirpour R, Homer B, Mathur S, Li Y, Li Z, Brown T, et al.
Toxicol Sci
. 2015 Aug;
148(1):35-47.
PMID: 26253709
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate protein levels posttranscriptionally. miRNAs play important regulatory roles in many cellular processes and have been implicated in several diseases. Recent studies have...
5.
Homer B, Morton D, Bagi C, Warneke J, Andresen C, Whiteley L, et al.
Toxicol Pathol
. 2014 Aug;
43(3):411-23.
PMID: 25142129
Orally administered small molecule agonists of soluble guanylate cyclase (sGC) induced increased numbers of osteoclasts, multifocal bone resorption, increased porosity, and new bone formation in the appendicular and axial skeleton...
6.
Nassirpour R, Mathur S, Gosink M, Li Y, Shoieb A, Wood J, et al.
BMC Genomics
. 2014 Jun;
15:485.
PMID: 24942259
Background: MicroRNAs (miRNAs) are small, non-coding RNAs that regulate protein levels post-transcriptionally. miRNAs play important regulatory roles in many cellular processes and have been implicated in several diseases. Recent studies...
7.
Rankin A, Seth N, Keegan S, Andreyeva T, Cook T, Edmonds J, et al.
J Immunol
. 2013 Sep;
191(9):4540-50.
PMID: 24068666
Autoantibody production and immune complex deposition within the kidney promote renal disease in patients with lupus nephritis. Thus, therapeutics that inhibit these pathways may be efficacious in the treatment of...
8.
Meyers M, Arhancet G, Hockerman S, Chen X, Long S, Mahoney M, et al.
J Med Chem
. 2010 Aug;
53(16):5979-6002.
PMID: 20672822
We have discovered a novel class of nonsteroidal pyrazoline antagonists of the mineralocorticoid receptor (MR) that show excellent potency and selectivity against other nuclear receptors. Early analogues were poorly soluble...
9.
Jacobson E, Homer B, Stacy B, Greiner E, Szabo N, Chrisman C, et al.
Dis Aquat Organ
. 2006 Aug;
70(1-2):139-54.
PMID: 16875401
Beginning in October 2000, subadult loggerhead sea turtles Caretta caretta showing clinical signs of a neurological disorder were found in waters off south Florida, USA. Histopathology indicated generalized and neurologic...
10.
Romero C, Meade P, Homer B, Shultz J, Lollis G
J Wildl Dis
. 2003 Oct;
39(3):567-75.
PMID: 14567217
Free-ranging feral swine (Sus scrofa) are known to be present in at least 32 states of the USA and are continuously expanding their range. Infection with pseudorabies virus (PRV) occurs...