Bruce J Shenker
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Explore the profile of Bruce J Shenker including associated specialties, affiliations and a list of published articles.
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29
Citations
536
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Recent Articles
1.
Kim T, MacElroy A, Defreitas A, Shenker B, Boesze-Battaglia K
Dent J (Basel)
. 2024 Jul;
12(7).
PMID: 39056982
Our research explores the interplay between () cytolethal distending toxin (Cdt) and the host's inflammatory response in molar/incisor pattern periodontitis (MIPP). Cdt disrupts phosphatidylinositol-3,4,5-triphosphate (PIP3) signaling, influencing cytokine expression through...
2.
Boesze-Battaglia K, Cohen G, Bates P, Walker L, Zekavat A, Shenker B
Front Cell Infect Microbiol
. 2024 May;
14:1334224.
PMID: 38698905
cytolethal distending toxin (Cdt) is capable of intoxicating lymphocytes macrophages, mast cells and epithelial cells. Following Cdt binding to cholesterol, in the region of membrane lipid rafts, the CdtB and...
3.
Shenker B, Korostoff J, Walker L, Zekavat A, Dhingra A, Kim T, et al.
Pathogens
. 2024 Feb;
13(2).
PMID: 38392893
Recently, we reported that oral-epithelial cells (OE) are unique in their response to cytolethal distending toxin (Cdt) in that cell cycle arrest (G2/M) occurs without leading to apoptosis. We now...
4.
Kim T, Shenker B, MacElroy A, Spradlin S, Walker L, Boesze-Battaglia K
Front Cell Infect Microbiol
. 2023 Nov;
13:1321218.
PMID: 37965259
[This corrects the article DOI: 10.3389/fcimb.2023.1220089.].
5.
Kim T, Shenker B, MacElory A, Spradlin S, Walker L, Boesze-Battaglia K
Front Cell Infect Microbiol
. 2023 Sep;
13:1220089.
PMID: 37719670
Cytolethal distending toxins (Cdt) are a family of toxins produced by several human pathogens which infect mucocutaneous tissue and induce inflammatory disease. Human macrophages exposed to () Cdt respond through...
6.
Shenker B, Walker L, Zekavat A, Korostoff J, Boesze-Battaglia K
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36233133
Cytolethal distending toxins (Cdt) are produced by a diverse group of pathogens. One Cdt-producing organism, , plays a critical role in the pathogenesis of a unique form of periodontitis, formerly...
7.
Huang G, Boesze-Battaglia K, Walker L, Zekavat A, Schaefer Z, Blanke S, et al.
Front Cell Infect Microbiol
. 2021 Apr;
11:664221.
PMID: 33854985
Human lymphocytes exposed to (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinositol...
8.
Boesze-Battaglia K, Dhingra A, Walker L, Zekavat A, Shenker B
Front Immunol
. 2020 Jul;
11:1262.
PMID: 32655562
The cytolethal distending toxin (Cdt) is a heterotrimeric AB toxin capable of inducing cell cycle arrest and apoptosis in lymphocytes and other cell types. Recently, we have demonstrated that human...
9.
Shenker B, Walker L, Zekavat Z, Ojcius D, Huang P, Boesze-Battaglia K
Cell Microbiol
. 2020 Feb;
22(7):e13194.
PMID: 32068949
Cytolethal distending toxins (Cdt) are a family of toxins produced by several human pathogens which infect mucocutaneous tissue and induce inflammatory disease. We have previously demonstrated that the Aggregatibacter actinomycetemcomitans...
10.
Shenker B, Walker L, Zekavat A, Weiss R, Boesze-Battaglia K
Pathogens
. 2020 Jan;
9(1).
PMID: 31906446
The cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21 is critical to...