Ali Zekavat
Overview
Explore the profile of Ali Zekavat including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
366
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Recent Articles
1.
Boesze-Battaglia K, Cohen G, Bates P, Walker L, Zekavat A, Shenker B
Front Cell Infect Microbiol
. 2024 May;
14:1334224.
PMID: 38698905
cytolethal distending toxin (Cdt) is capable of intoxicating lymphocytes macrophages, mast cells and epithelial cells. Following Cdt binding to cholesterol, in the region of membrane lipid rafts, the CdtB and...
2.
Shenker B, Korostoff J, Walker L, Zekavat A, Dhingra A, Kim T, et al.
Pathogens
. 2024 Feb;
13(2).
PMID: 38392893
Recently, we reported that oral-epithelial cells (OE) are unique in their response to cytolethal distending toxin (Cdt) in that cell cycle arrest (G2/M) occurs without leading to apoptosis. We now...
3.
Shenker B, Walker L, Zekavat A, Korostoff J, Boesze-Battaglia K
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36233133
Cytolethal distending toxins (Cdt) are produced by a diverse group of pathogens. One Cdt-producing organism, , plays a critical role in the pathogenesis of a unique form of periodontitis, formerly...
4.
Huang G, Boesze-Battaglia K, Walker L, Zekavat A, Schaefer Z, Blanke S, et al.
Front Cell Infect Microbiol
. 2021 Apr;
11:664221.
PMID: 33854985
Human lymphocytes exposed to (Aa) cytolethal distending toxin (Cdt) undergo cell cycle arrest and apoptosis. In previous studies, we demonstrated that the active Cdt subunit, CdtB, is a potent phosphatidylinositol...
5.
Boesze-Battaglia K, Dhingra A, Walker L, Zekavat A, Shenker B
Front Immunol
. 2020 Jul;
11:1262.
PMID: 32655562
The cytolethal distending toxin (Cdt) is a heterotrimeric AB toxin capable of inducing cell cycle arrest and apoptosis in lymphocytes and other cell types. Recently, we have demonstrated that human...
6.
Shenker B, Walker L, Zekavat A, Weiss R, Boesze-Battaglia K
Pathogens
. 2020 Jan;
9(1).
PMID: 31906446
The cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB. We now demonstrate that p21 is critical to...
7.
Shenker B, Boesze-Battaglia K, Scuron M, Walker L, Zekavat A, Dlakic M
Cell Microbiol
. 2015 Aug;
18(2):223-43.
PMID: 26247396
The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes and other cell types. We have shown that the active subunit, CdtB, exhibits phosphatidylinositol-3,4,5-triphosphate (PIP3) phosphatase...
8.
Boesze-Battaglia K, Walker L, Zekavat A, Dlakic M, Scuron M, Nygren P, et al.
Infect Immun
. 2015 Jul;
83(10):4042-55.
PMID: 26216427
Induction of cell cycle arrest in lymphocytes following exposure to the Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) is dependent upon the integrity of lipid membrane microdomains. Moreover, we have previously...
9.
Shenker B, Ojcius D, Walker L, Zekavat A, Scuron M, Boesze-Battaglia K
Infect Immun
. 2015 Feb;
83(4):1487-96.
PMID: 25644004
The cytolethal distending toxin (Cdt) is produced from a number of bacteria capable of causing infection and inflammatory disease. Our previous studies with Actinobacillus actinomycetemcomitans Cdt demonstrate not only that...
10.
Shenker B, Walker L, Zekavat A, Dlakic M, Boesze-Battaglia K
Cell Microbiol
. 2014 Apr;
16(9):1391-404.
PMID: 24697951
The Aggregatibactor actinomycetemcomitans cytolethal distending toxin (Cdt) induces G2 arrest and apoptosis in lymphocytes; these toxic effects are due to the active subunit, CdtB, which functions as a phosphatidylinositol-3,4,5-triphosphate (PIP3)...