Bruce F OHara
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Explore the profile of Bruce F OHara including associated specialties, affiliations and a list of published articles.
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2383
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Recent Articles
1.
Kane K, Iradukunda D, McLouth C, Guo L, Wang J, Subramoniam A, et al.
J Sleep Res
. 2025 Jan;
e14461.
PMID: 39873354
The neuronal ceroid lipofuscinoses (NCLs) are a group of recessively inherited neurodegenerative diseases characterizsed by lysosomal storage of fluorescent materials. CLN3 disease, or juvenile Batten disease, is the most common...
2.
Wang J, Huffman D, Ajwad A, McLouth C, Bachstetter A, Kohler K, et al.
Sleep
. 2024 Mar;
47(6).
PMID: 38512801
Accumulation of amyloid-β (Aβ) plays an important role in Alzheimer's disease (AD) pathology. There is growing evidence that disordered sleep may accelerate AD pathology by impeding the physiological clearance of...
3.
Huffman D, Ajwad A, Agarwal A, Lhamon M, Donohue K, OHara B, et al.
J Neurosci Methods
. 2024 Feb;
404:110063.
PMID: 38301833
Background: Sleep perturbation is widely used to investigate the physiological mechanisms that mediate sleep-wake dynamics, and to isolate the specific roles of sleep in health and disease. However, state-of-the-art methods...
4.
Costello A, Linning-Duffy K, Vandenbrook C, Donohue K, OHara B, Kim A, et al.
J Affect Disord
. 2023 Apr;
332:299-308.
PMID: 37060954
Background: Bright light therapy (BLT) is the first-line treatment for seasonal affective disorder. However, the neural mechanisms underlying BLT are unclear. To begin filling this gap, the present study examined...
5.
Lituma P, Woo E, OHara B, Castillo P, Sibinga N, Nandi S
Proc Natl Acad Sci U S A
. 2021 Nov;
118(46).
PMID: 34764226
Growing evidence indicates that microglia impact brain function by regulating synaptic pruning and formation as well as synaptic transmission and plasticity. Iba1 (ionized Ca-binding adapter protein 1), encoded by the...
6.
Huffman D, Ajwad A, Yaghouby F, OHara B, Sunderam S
J Sleep Res
. 2021 Jan;
30(4):e13262.
PMID: 33403714
Subtle changes in sleep architecture can accompany and be symptomatic of many diseases or disorders. In order to probe and understand the complex interactions between sleep and health, the ability...
7.
Bubier J, He H, Philip V, Roy T, Monroy Hernandez C, Bernat R, et al.
Sci Rep
. 2020 Sep;
10(1):14970.
PMID: 32917924
In the U.S., opioid prescription for treatment of pain nearly quadrupled from 1999 to 2014. The diversion and misuse of prescription opioids along with increased use of drugs like heroin...
8.
Wang C, Guerriero L, Huffman D, Ajwad A, Brooks T, Sunderam S, et al.
Sci Rep
. 2020 Jul;
10(1):10944.
PMID: 32616800
Most published sleep studies use three species: human, house mouse, or Norway rat. The degree to which data from these species captures variability in mammalian sleep remains unclear. To gain...
9.
Jan M, OHara B, Franken P
F1000Res
. 2020 Apr;
9.
PMID: 32274013
Sleep is a ubiquitous and complex behavior in both its manifestation and regulation. Despite its essential role in maintaining optimal performance, health, and well-being, the genetic mechanisms underlying sleep remain...
10.
Mishra I, Pullum K, Thayer D, Plummer E, Conkright B, Morris A, et al.
Am J Physiol Regul Integr Comp Physiol
. 2020 Mar;
318(4):R781-R789.
PMID: 32130024
Sleep loss contributes to the development of cardiovascular, metabolic, and neurological disorders by promoting a systemic proinflammatory phenotype. The neuroendocrine-immune mechanisms contributing to such pathologies are poorly understood. The sympathetic...