Brooks H Pate
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Explore the profile of Brooks H Pate including associated specialties, affiliations and a list of published articles.
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64
Citations
324
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Recent Articles
1.
Dabbs J, Taylor C, Holdren M, Brewster S, Quillin B, Meng A, et al.
Nat Commun
. 2024 Sep;
15(1):8473.
PMID: 39349937
Methods are lacking that can prepare deuterium-enriched building blocks, in the full range of deuterium substitution patterns at the isotopic purity levels demanded by pharmaceutical use. To that end, this...
2.
Neill J, Evangelisti L, Pate B
Anal Sci Adv
. 2024 May;
4(5-6):204-219.
PMID: 38716067
Recent developments in molecular rotational resonance (MRR) spectroscopy that have enabled its use as an analytical technique for the precise determination of molecular structure are reviewed. In particular, its use...
3.
Cheng A, Lo A, Miret S, Pate B, Aspuru-Guzik A
J Chem Phys
. 2024 Mar;
160(12).
PMID: 38545949
Structure determination is necessary to identify unknown organic molecules, such as those in natural products, forensic samples, the interstellar medium, and laboratory syntheses. Rotational spectroscopy enables structure determination by providing...
4.
Sonstrom R, Vang Z, Scolati H, Neill J, Pate B, Clark J
Org Process Res Dev
. 2023 Dec;
27(7):1185-1197.
PMID: 38046274
Recent work in drug discovery has shown that selectively deuterated small molecules can improve the safety and efficacy for active pharmaceutical ingredients. The advantages derive from changes in metabolism resulting...
5.
Sloane S, Vang Z, Nelson G, Qi L, Sonstrom R, Alansari I, et al.
JACS Au
. 2023 Jun;
3(6):1583-1589.
PMID: 37388686
A highly regio- and chemoselective Cu-catalyzed aryl alkyne transfer hydrodeuteration to access a diverse scope of aryl alkanes precisely deuterated at the benzylic position is described. The reaction benefits from...
6.
Vang Z, Sonstrom R, Scolati H, Clark J, Pate B
Chirality
. 2023 Jun;
35(11):856-883.
PMID: 37277968
Chiral tag molecular rotational resonance (MRR) spectroscopy is used to assign the absolute configuration of molecules that are chiral by virtue of deuterium substitution. Interest in the improved performance of...
7.
Mayer K, West C, Marshall F, Sedo G, Grubbs 2nd G, Evangelisti L, et al.
Phys Chem Chem Phys
. 2022 Nov;
24(45):27705-27721.
PMID: 36374162
The absolute configuration of a molecule can be established by analysis of molecular rotational spectra of the analyte complexed with a small chiral molecule of known configuration. This approach of...
8.
Baweja S, Panchagnula S, Eugenia Sanz M, Evangelisti L, Perez C, West C, et al.
J Phys Chem Lett
. 2022 Oct;
13(40):9510-9516.
PMID: 36200782
Non-covalent interactions between aromatic molecules and water are fundamental in many chemical and biological processes, and their accurate description is essential to understand molecular relative configurations. Here we present the...
9.
Mills M, Sonstrom R, Vang Z, Neill J, Scolati H, West C, et al.
Angew Chem Int Ed Engl
. 2022 Jun;
61(33):e202207275.
PMID: 35700045
Fundamental to the synthesis of enantioenriched chiral molecules is the ability to assign absolute configuration at each stereogenic center, and to determine the enantiomeric excess for each compound. While determination...
10.
Steber A, Li W, Pate B, Lesarri A, Perez C
J Phys Chem Lett
. 2022 Apr;
13(16):3770-3775.
PMID: 35446045
Self-aggregation of sevoflurane, an inhalable, fluorinated anesthetic, provides a challenge for current state-of-the-art high-resolution techniques due to its large mass and the variety of possible hydrogen bonds between monomers. Here...