Brooke K McMichael
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Explore the profile of Brooke K McMichael including associated specialties, affiliations and a list of published articles.
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10
Citations
165
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Recent Articles
1.
Kim D, Jeong Y, McMichael B, Bahler M, Bodnyk K, Sedlar R, et al.
J Mech Behav Biomed Mater
. 2018 May;
84:99-107.
PMID: 29754047
The objective of this study was to examine relationships among a variety of bone characteristics, including volumetric, mineral density, geometric, dynamic mechanical analysis, and static fracture mechanical properties. As MYO9B...
2.
McMichael B, Jeong Y, Auerbach J, Han C, Sedlar R, Shettigar V, et al.
J Bone Miner Res
. 2017 Jun;
32(10):2103-2115.
PMID: 28585695
The Ras homolog A (RhoA) subfamily of Rho guanosine triphosphatases (GTPases) regulates actin-based cellular functions in bone such as differentiation, migration, and mechanotransduction. Polymorphisms or genetic ablation of RHOA and...
3.
McMichael B, Scherer K, Franklin N, Lee B
PLoS One
. 2014 Jan;
9(1):e87402.
PMID: 24466350
Osteoclasts are large, multinucleated cells of the monocyte-macrophage lineage that generate specialized substrate adhesion complexes to facilitate their function as bone-degrading cells. The patterning and function of these actin-based complexes,...
4.
Aggarwal R, Lu J, Kanji S, Joseph M, Das M, Noble G, et al.
PLoS One
. 2012 Jun;
7(6):e39365.
PMID: 22724005
Background: Osteoporosis is a bone disorder associated with loss of bone mineral density and micro architecture. A balance of osteoblasts and osteoclasts activities maintains bone homeostasis. Increased bone loss due...
5.
McMichael B, Meyer S, Lee B
J Biol Chem
. 2010 Jun;
285(34):26641-51.
PMID: 20547766
Osteoclasts resorb bone through the formation of a unique attachment structure called the sealing zone. In this study, a role for thyroid hormone receptor-interacting protein 6 (TRIP6) in sealing zone...
6.
McMichael B, Cheney R, Lee B
J Biol Chem
. 2010 Jan;
285(13):9506-9515.
PMID: 20081229
Osteoclasts use actin-rich attachment structures in place of focal adhesions for adherence to bone and non-bone substrates. On glass, osteoclasts generate podosomes, foot-like processes containing a core of F-actin and...
7.
McMichael B, Wysolmerski R, Lee B
J Biol Chem
. 2009 Mar;
284(18):12266-75.
PMID: 19269977
The nonmuscle myosin IIA heavy chain (Myh9) is strongly associated with adhesion structures of osteoclasts. In this study, we demonstrate that during osteoclastogenesis, myosin IIA heavy chain levels are temporarily...
8.
Kotadiya P, McMichael B, Lee B
Bone
. 2008 Aug;
43(5):951-60.
PMID: 18674650
Tropomyosins are coiled-coil dimers that bind to the major groove of F-actin and regulate its accessibility to actin-modifying proteins. Although approximately 40 tropomyosin isoforms have been identified in mammals, they...
9.
McMichael B, Lee B
Exp Cell Res
. 2007 Nov;
314(3):564-73.
PMID: 18036591
Tropomyosins (Tms) are alpha-helical dimers that bind and stabilize actin microfilaments while regulating their accessibility to other actin-associated proteins. Four genes encode expression of over forty Tms, most of which...
10.
McMichael B, Kotadiya P, Singh T, Holliday L, Lee B
Bone
. 2006 Jun;
39(4):694-705.
PMID: 16765662
Osteoclasts resorb bone through transient rearrangement of their cytoskeletons to create a polarized phenotype in which an apical ruffled membrane is surrounded by a ring of F-actin that creates a...