Brooke C Harrison
Overview
Explore the profile of Brooke C Harrison including associated specialties, affiliations and a list of published articles.
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23
Citations
1646
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Recent Articles
1.
Hanson A, Young M, Harrison B, Zhou X, Han H, Stodieck L, et al.
NPJ Microgravity
. 2023 Jan;
9(1):2.
PMID: 36646717
Novel treatments for muscle wasting are of significant value to patients with disease states that result in muscle weakness, injury recovery after immobilization and bed rest, and for astronauts participating...
2.
Tan Y, Martin T, Harrison B, Leinwand L
J Muscle Res Cell Motil
. 2022 Nov;
44(2):95-106.
PMID: 36316565
Non-traditional animal models present an opportunity to discover novel biology that has evolved to allow such animals to survive in extreme environments. One striking example is the Burmese python (Python...
3.
Magida J, Tan Y, Wall C, Harrison B, Marr T, Peter A, et al.
J Gen Physiol
. 2022 Mar;
154(4).
PMID: 35323838
As an opportunistic predator, the Burmese python (Python molurus bivittatus) consumes large and infrequent meals, fasting for up to a year. Upon consuming a large meal, the Burmese python exhibits...
4.
Bjorkman K, Guess M, Harrison B, Polmear M, Peter A, Leinwand L
J Cell Sci
. 2020 Jul;
133(15).
PMID: 32620696
Striated muscle is a highly specialized collection of tissues with contractile properties that vary according to functional needs. Although muscle fiber types are established postnatally, lifelong plasticity facilitates stimulus-dependent adaptation....
5.
A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice
Green E, Wakimoto H, Anderson R, Evanchik M, Gorham J, Harrison B, et al.
Science
. 2016 Feb;
351(6273):617-21.
PMID: 26912705
Hypertrophic cardiomyopathy (HCM) is an inherited disease of heart muscle that can be caused by mutations in sarcomere proteins. Clinical diagnosis depends on an abnormal thickening of the heart, but...
6.
Lemon D, Harrison B, Horn T, Stratton M, Ferguson B, Wempe M, et al.
FEBS Lett
. 2015 Mar;
589(10):1080-8.
PMID: 25816750
PKD-mediated phosphorylation of class IIa HDACs frees the MEF2 transcription factor to activate genes that govern muscle differentiation and growth. Studies of the regulation and function of this signaling axis...
7.
Guess M, Barthel K, Harrison B, Leinwand L
PLoS One
. 2015 Feb;
10(2):e0118229.
PMID: 25689854
microRNAs (miRNAs) are short non-coding RNAs that can mediate changes in gene expression and are required for the formation of skeletal muscle (myogenesis). With the goal of identifying novel miRNA...
8.
Hanson A, Harrison B, Young M, Stodieck L, Ferguson V
Muscle Nerve
. 2013 Jul;
48(3):393-402.
PMID: 23893872
Introduction: Hindlimb unloading-induced muscle atrophy is often assessed after a homeostatic state is established, thus overlooking the early adaptations that are critical to developing this pattern of atrophy. Methods: Muscle...
9.
Ferguson B, Harrison B, Jeong M, Reid B, Wempe M, Wagner F, et al.
Proc Natl Acad Sci U S A
. 2013 May;
110(24):9806-11.
PMID: 23720316
Cardiac hypertrophy is a strong predictor of morbidity and mortality in patients with heart failure. Small molecule histone deacetylase (HDAC) inhibitors have been shown to suppress cardiac hypertrophy through mechanisms...
10.
Leinwand L, Harrison B
Cell
. 2013 May;
153(4):743-5.
PMID: 23663775
In this issue of Cell, Loffredo et al. demonstrate that exposing an old mouse to the circulatory system of a young mouse reverses age-related cardiac hypertrophy. The authors demonstrate that...