Brigitte Gasser
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Explore the profile of Brigitte Gasser including associated specialties, affiliations and a list of published articles.
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101
Citations
2957
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Recent Articles
1.
Kostopoulou A, Rebnegger C, Ferrero-Bordera B, Mattanovich M, Maass S, Becher D, et al.
Microb Biotechnol
. 2025 Feb;
18(2):e70106.
PMID: 39937160
The yeast Komagataella phaffii (syn. Pichia pastoris) is a highly effective and well-established host for the production of recombinant proteins. The redox balance of its secretory pathway, which is multi-organelle...
2.
Rebnegger C, Flores-Villegas M, Kowarz V, De S, Pusterla A, Holm H, et al.
N Biotechnol
. 2024 Oct;
84:105-114.
PMID: 39384085
Flo8 is a main transcriptional regulator of flocculation and pseudohyphal growth in yeast. Disruption of FLO8 in the popular recombinant protein production host Komagataella phaffii (Pichia pastoris) prevents pseudohyphal growth...
3.
Palma A, Rettenbacher L, Moilanen A, Saaranen M, Gasser B, Ruddock L
J Biol Chem
. 2024 Feb;
300(3):105746.
PMID: 38354787
In the methylotrophic yeast Komagataella phaffii, we identified an endoplasmic reticulum-resident protein disulfide isomerase (PDI) family member, Erp41, with a peculiar combination of active site motifs. Like fungal ERp38, it...
4.
Rebnegger C, Coltman B, Kowarz V, Pena D, Mentler A, Troyer C, et al.
Microb Cell Fact
. 2024 Feb;
23(1):43.
PMID: 38331812
Background: Specific productivity (q) in yeast correlates with growth, typically peaking at intermediate or maximum specific growth rates (μ). Understanding the factors limiting productivity at extremely low μ might reveal...
5.
Coltman B, Rebnegger C, Gasser B, Zanghellini J
Microb Biotechnol
. 2024 Jan;
17(1):e14386.
PMID: 38206275
Retentostat cultivations have enabled investigations into substrate-limited near-zero growth for a number of microbes. Quantitative physiology at these near-zero growth conditions has been widely discussed, yet characterisation of the fluxome...
6.
Flores-Villegas M, Rebnegger C, Kowarz V, Prielhofer R, Mattanovich D, Gasser B
Nucleic Acids Res
. 2023 Oct;
51(20):11358-11374.
PMID: 37791854
The promoter of the high-affinity glucose transporter Gth1 (PGTH1) is tightly repressed on glucose and glycerol surplus, and strongly induced in glucose-limitation, thus enabling regulated methanol-free production processes in the...
7.
Russmayer H, Buchetics M, Mattanovich M, Neubauer S, Steiger M, Graf A, et al.
Biotechnol J
. 2023 Sep;
18(12):e2300033.
PMID: 37668396
Amino acids are the building blocks of proteins. In this respect, a reciprocal effect of recombinant protein production on amino acid biosynthesis as well as the impact of the availability...
8.
Palma A, Rettenbacher L, Moilanen A, Saaranen M, Pacheco-Martinez C, Gasser B, et al.
Sci Rep
. 2023 Aug;
13(1):14298.
PMID: 37652992
Oxidative protein folding in the endoplasmic reticulum (ER) is driven mainly by protein disulfide isomerase PDI and oxidoreductin Ero1. Their activity is tightly regulated and interconnected with the unfolded protein...
9.
Zahrl R, Prielhofer R, Burgard J, Mattanovich D, Gasser B
N Biotechnol
. 2023 Jan;
73:19-28.
PMID: 36603701
Yeasts, such as Pichia pastoris (syn Komagataella spp.), are particularly suitable expression systems for emerging classes of recombinant proteins. Among them, recombinant antibody fragments, such as single-chain variable fragments (scFv)...
10.
Pushing and pulling proteins into the yeast secretory pathway enhances recombinant protein secretion
Zahrl R, Prielhofer R, Ata O, Baumann K, Mattanovich D, Gasser B
Metab Eng
. 2022 Sep;
74:36-48.
PMID: 36057427
Yeasts and especially Pichia pastoris (syn Komagataella spp.) are popular microbial expression systems for the production of recombinant proteins. One of the key advantages of yeast host systems is their...