Brig Mecham
Overview
Explore the profile of Brig Mecham including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
6
Citations
257
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0
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Recent Articles
1.
Axelsson A, Tubbs E, Mecham B, Chacko S, Nenonen H, Tang Y, et al.
Sci Transl Med
. 2017 Jun;
9(394).
PMID: 28615356
A potentially useful approach for drug discovery is to connect gene expression profiles of disease-affected tissues ("disease signatures") to drug signatures, but it remains to be shown whether it can...
2.
Smith J, Hing A, Clarke C, Johnson N, Perez F, Park S, et al.
Am J Hum Genet
. 2014 Aug;
95(2):235-40.
PMID: 25105228
Acromelic frontonasal dysostosis (AFND) is a rare disorder characterized by distinct craniofacial, brain, and limb malformations, including frontonasal dysplasia, interhemispheric lipoma, agenesis of the corpus callosum, tibial hemimelia, preaxial polydactyly...
3.
Dey J, Dubuc A, Pedro K, Thirstrup D, Mecham B, Northcott P, et al.
Cancer Res
. 2013 Oct;
73(22):6828-37.
PMID: 24092238
While medulloblastoma, a pediatric tumor of the cerebellum, is characterized by aberrations in developmental pathways, the majority of genetic determinants remain unknown. An unbiased Sleeping Beauty transposon screen revealed MyoD...
4.
Dey J, Ditzler S, Knoblaugh S, Hatton B, Schelter J, Cleary M, et al.
Mol Cell Biol
. 2012 Aug;
32(20):4104-15.
PMID: 22869526
Deregulated developmental processes in the cerebellum cause medulloblastoma, the most common pediatric brain malignancy. About 25 to 30% of cases are caused by mutations increasing the activity of the Sonic...
5.
Stamper B, Park S, Beyer R, Bammler T, Farin F, Mecham B, et al.
PLoS One
. 2011 Oct;
6(10):e26557.
PMID: 22028906
Craniosynostosis is a disease defined by premature fusion of one or more cranial sutures. The mechanistic pathology of single-suture craniosynostosis is complex and while a number of genetic biomarkers and...
6.
Pritchard C, Mecham B, Dumpit R, Coleman I, Bhattacharjee M, Chen Q, et al.
Cancer Res
. 2009 Feb;
69(5):1739-47.
PMID: 19223557
Studies centered at the intersection of embryogenesis and carcinogenesis have identified striking parallels involving signaling pathways that modulate both developmental and neoplastic processes. In the prostate, reciprocal interactions between epithelium...