Bridgette A Barry
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Explore the profile of Bridgette A Barry including associated specialties, affiliations and a list of published articles.
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78
Citations
578
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Recent Articles
1.
Safiarian M, Watson R, Lieberman R, Barry B, Offenbacher A
J Phys Chem Lett
. 2021 Sep;
12(37):9020-9025.
PMID: 34516127
Ribonucleotide reductase (RNR), which supplies the building blocks for DNA biosynthesis and its repair, has been linked to human diseases and is emerging as a therapeutic target. Here, we present...
2.
Watson R, Offenbacher A, Barry B
J Phys Chem B
. 2021 Jul;
125(30):8362-8372.
PMID: 34289692
The enzyme, ribonucleotide reductase (RNR), is essential for DNA synthesis in all cells. The class Ia RNR consists of two dimeric subunits, α and β, which form an active but...
3.
Offenbacher A, Barry B
J Phys Chem B
. 2020 Jan;
124(2):345-354.
PMID: 31904962
Proton-coupled electron transfer (PCET) is fundamental to many important biological reactions, including solar energy conversion and DNA synthesis. For example, class Ia ribonucleotide reductases (RNRs) contain a tyrosyl radical-diiron cofactor...
4.
McCaslin T, Pagba C, Yohannan J, Barry B
Sci Rep
. 2019 Nov;
9(1):17303.
PMID: 31754129
Histatin-5 (Hst-5) is an antimicrobial, salivary protein that is involved in the host defense system. Hst-5 has been proposed to bind functionally relevant zinc and copper but presents challenges in...
5.
McCaslin T, Pagba C, Hwang H, Gumbart J, Chi S, Perry J, et al.
Chem Commun (Camb)
. 2019 Jul;
55(63):9399-9402.
PMID: 31322154
Tyrosine residues act as intermediates in proton coupled electron transfer reactions (PCET) in proteins. For example, in ribonucleotide reductase (RNR), a tyrosyl radical oxidizes an active site cysteine via a...
6.
Brahmachari U, Gonthier J, Sherrill C, Barry B
J Phys Chem B
. 2019 May;
123(21):4487-4496.
PMID: 31099580
Proton transfer using water bridges has been observed in bulk water, acid-base reactions, and several proton-translocating biological systems. In the photosynthetic water-oxidizing enzyme, photosystem II (PSII), protons from substrate water...
7.
McCaslin T, Pagba C, Chi S, Hwang H, Gumbart J, Perry J, et al.
J Phys Chem B
. 2019 Mar;
123(13):2780-2791.
PMID: 30888824
Tyrosine-tryptophan (YW) dyads are ubiquitous structural motifs in enzymes and play roles in proton-coupled electron transfer (PCET) and, possibly, protection from oxidative stress. Here, we describe the function of YW...
8.
Robbins J, Geng J, Barry B, Gadda G, Bommarius A
Biochemistry
. 2018 Sep;
57(40):5818-5826.
PMID: 30226367
Formate oxidase (FOX) was previously shown to contain a noncovalently bound 8-formyl FAD (8-fFAD) cofactor. However, both the absorption spectra and the kinetic parameters previously reported for FOX are inconsistent...
9.
Brahmachari U, Guo Z, Konecny S, Obi E, Barry B
J Phys Chem B
. 2018 Jun;
122(26):6702-6711.
PMID: 29924605
Photosystem II oxidizes water at a MnCaO cluster. Oxygen evolution is accompanied by proton release through a 35 Å hydrogen-bonding network to the lumen. The mechanism of this proton-transfer reaction...
10.
Guo Z, He J, Barry B
Proc Natl Acad Sci U S A
. 2018 May;
115(22):5658-5663.
PMID: 29752381
In Photosystem II (PSII), YZ (Tyr161D1) participates in radical transfer between the chlorophyll donor and the MnCaO cluster. Under flashing illumination, the metal cluster cycles among five S states, and...