Brian Y H Lam
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Explore the profile of Brian Y H Lam including associated specialties, affiliations and a list of published articles.
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42
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1278
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Recent Articles
11.
Duckett K, Williamson A, Kincaid J, Rainbow K, Corbin L, Martin H, et al.
J Clin Endocrinol Metab
. 2023 Jun;
108(12):e1580-e1587.
PMID: 37339320
Context: The melanocortin 3 receptor (MC3R) has recently emerged as a critical regulator of pubertal timing, linear growth, and the acquisition of lean mass in humans and mice. In population-based...
12.
Ramos-Pittol J, Fernandes-Freitas I, Milona A, Manchishi S, Rainbow K, Lam B, et al.
Nat Commun
. 2023 May;
14(1):3076.
PMID: 37248237
Coupling the release of pituitary hormones to the developmental stage of the oocyte is essential for female fertility. It requires estrogen to restrain kisspeptin (KISS1)-neuron pulsatility in the arcuate hypothalamic...
13.
Saeed S, Ning L, Badreddine A, Mirza M, Boissel M, Khanam R, et al.
Diabetes
. 2023 Apr;
72(9):1228-1234.
PMID: 37083980
We previously demonstrated that 50% of children with obesity from consanguineous families from Pakistan carry pathogenic variants in known monogenic obesity genes. Here, we have discovered a novel monogenetic recessive...
14.
Asami M, Lam B, Hoffmann M, Suzuki T, Lu X, Yoshida N, et al.
Cell Rep
. 2023 Feb;
42(2):112023.
PMID: 36729835
At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset of embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing...
15.
Wagner S, Brierley D, Leeson-Payne A, Jiang W, Chianese R, Lam B, et al.
Mol Metab
. 2023 Jan;
68:101665.
PMID: 36592795
Objective: Overweight and obesity are endemic in developed countries, with a substantial negative impact on human health. Medications developed to treat obesity include agonists for the G-protein coupled receptors glucagon-like...
16.
Steuernagel L, Lam B, Klemm P, Dowsett G, Bauder C, Tadross J, et al.
Nat Metab
. 2022 Oct;
4(10):1402-1419.
PMID: 36266547
The hypothalamus plays a key role in coordinating fundamental body functions. Despite recent progress in single-cell technologies, a unified catalog and molecular characterization of the heterogeneous cell types and, specifically,...
17.
Perry A, Asami M, Lam B, Yeo G
Trends Cell Biol
. 2022 Oct;
33(5):365-373.
PMID: 36182534
Gamete (sperm and oocyte) genomes are transcriptionally silent until embryonic genome activation (EGA) following fertilization. EGA in humans had been thought to occur around the eight-cell stage, but recent findings...
18.
Sandovici I, Georgopoulou A, Perez-Garcia V, Hufnagel A, Lopez-Tello J, Lam B, et al.
Dev Cell
. 2021 Dec;
57(1):63-79.e8.
PMID: 34963058
In all eutherian mammals, growth of the fetus is dependent upon a functional placenta, but whether and how the latter adapts to putative fetal signals is currently unknown. Here, we...
19.
Asami M, Lam B, Ma M, Rainbow K, Braun S, VerMilyea M, et al.
Cell Stem Cell
. 2021 Dec;
29(2):209-216.e4.
PMID: 34936886
In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs by the eight-cell stage, but its exact timing and profile are unclear. To address this, we profiled gene...
20.
Bidault G, Virtue S, Petkevicius K, Jolin H, Dugourd A, Guenantin A, et al.
Nat Metab
. 2021 Sep;
3(9):1150-1162.
PMID: 34531575
Macrophages exhibit a spectrum of activation states ranging from classical to alternative activation. Alternatively, activated macrophages are involved in diverse pathophysiological processes such as confining tissue parasites, improving insulin sensitivity...