Brian S Schaffhausen
Overview
Explore the profile of Brian S Schaffhausen including associated specialties, affiliations and a list of published articles.
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16
Citations
394
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Recent Articles
1.
A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling
Denis D, Rouleau C, Schaffhausen B
J Virol
. 2016 Nov;
91(2).
PMID: 27852846
Importance: The gene coding for middle T antigen (MT) is the murine polyomavirus oncogene most responsible for tumor formation. Its study has a history of uncovering novel aspects of mammalian...
2.
Rouleau C, Pores Fernando A, Hwang J, Faure N, Jiang T, White E, et al.
J Virol
. 2016 May;
90(16):7032-7045.
PMID: 27194756
Unlabelled: Murine polyomavirus has repeatedly provided insights into tumorigenesis, revealing key control mechanisms such as tyrosine phosphorylation and phosphoinositide 3-kinase (PI3K) signaling. We recently demonstrated that polyomavirus small T antigen...
3.
Hwang J, Pores Fernando A, Faure N, Andrabi S, Adelmant G, Hahn W, et al.
J Virol
. 2015 Jun;
89(13):6971.
PMID: 26041839
No abstract available.
4.
White E, Kramer R, Hwang J, Pores Fernando A, Naetar N, Hahn W, et al.
J Virol
. 2014 Dec;
89(5):2857-65.
PMID: 25540383
Unlabelled: Many of the small DNA tumor viruses encode transforming proteins that function by targeting critical cellular pathways involved in cell proliferation and survival. In this study, we have examined...
5.
Hwang J, Pores Fernando A, Faure N, Andrabi S, Adelmant G, Hahn W, et al.
J Virol
. 2014 Aug;
88(20):12055-64.
PMID: 25122798
Murine polyomavirus small t antigen (PyST) regulates cell cycle, cell survival, apoptosis, and differentiation and cooperates with middle T antigen (MT) to transform primary cells in vitro and in vivo....
6.
Utermark T, Schmit F, Lee S, Gao X, Schaffhausen B, Roberts T
J Virol
. 2014 Jul;
88(18):10673-9.
PMID: 24991009
Unlabelled: Previous work has shown that prostate cancer in a Pten-null murine model is dependent on the p110β isoform of phosphatidylinositol 3-kinase (PI3K), while breast cancer driven by either polyoma...
7.
Banerjee P, DeJesus R, Gjoerup O, Schaffhausen B
PLoS Pathog
. 2013 Nov;
9(10):e1003725.
PMID: 24204272
Correct repair of damaged DNA is critical for genomic integrity. Deficiencies in DNA repair are linked with human cancer. Here we report a novel mechanism by which a virus manipulates...
8.
Hwang J, Jiang T, Kulkarni S, Faure N, Schaffhausen B
J Biol Chem
. 2013 Sep;
288(44):32064-73.
PMID: 24052256
Protein phosphatase 2A (PP2A) regulates almost all cell signaling pathways. It consists of a scaffolding A subunit to which a catalytic C subunit and one of many regulatory B subunits...
9.
Andrabi S, Hwang J, Choe J, Roberts T, Schaffhausen B
J Virol
. 2011 Aug;
85(20):10649-58.
PMID: 21835797
Although members of a virus family produce similar gene products, those products may have quite different functions. Simian virus 40 (SV40) large T antigen (LT), for example, targets p53 directly,...
10.
Fluck M, Schaffhausen B
Microbiol Mol Biol Rev
. 2009 Sep;
73(3):542-63, Table of Contents.
PMID: 19721090
The small DNA tumor viruses have provided a very long-lived source of insights into many aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been...