Brian M Varisco
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Explore the profile of Brian M Varisco including associated specialties, affiliations and a list of published articles.
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36
Citations
387
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Recent Articles
1.
Aubert O, Miyake Y, Amonkar G, Dinwoodie O, Varisco B, Marotta M, et al.
Am J Respir Cell Mol Biol
. 2024 Dec;
PMID: 39661950
Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of the diaphragm. While the ensuing compression to the fetal lung causes lung hypoplasia, specific cellular phenotypes and developmental signaling defects...
2.
Devine A, Smith N, Joshi R, Brooks-Patton B, Dunham J, Varisco A, et al.
Chronic Obstr Pulm Dis
. 2024 Dec;
12(1):12-22.
PMID: 39636054
Background: Alpha-1 antitrypsin (AAT) deficiency is the most common genetic cause of emphysema. Chymotrypsin-like elastase 1 (CELA1) is a serine protease neutralized by AAT and is important in emphysema progression....
3.
Devine A, Smith N, Joshi R, Brooks-Patton B, Dunham J, Varisco A, et al.
bioRxiv
. 2024 May;
PMID: 38766202
Alpha-1 antitrypsin (AAT) deficiency is the most common genetic cause of emphysema. Chymotrypsin-like Elastase 1 (CELA1) is a serine protease neutralized by AAT and is important in emphysema progression. -deficiency...
4.
Whitney J, Johnson G, Varisco B, Raby B, Yehya N
Pediatr Crit Care Med
. 2024 Apr;
25(7):599-608.
PMID: 38591949
Objectives: The Pediatric Acute Respiratory Distress Syndrome Biomarker Risk Model (PARDSEVERE) used age and three plasma biomarkers measured within 24 hours of pediatric acute respiratory distress syndrome (ARDS) onset to...
5.
Yehya N, Booth T, Ardhanari G, Thompson J, Lam L, Till J, et al.
J Clin Invest
. 2024 Apr;
134(10).
PMID: 38573766
BACKGROUNDThe molecular signature of pediatric acute respiratory distress syndrome (ARDS) is poorly described, and the degree to which hyperinflammation or specific tissue injury contributes to outcomes is unknown. Therefore, we...
6.
Ojha M, Smith N, Devine A, Joshi R, Goodman E, Fan Q, et al.
JCI Insight
. 2024 Jan;
9(1).
PMID: 38193533
There are no therapies to prevent emphysema progression. Chymotrypsin-like elastase 1 (CELA1) is a serine protease that binds and cleaves lung elastin in a stretch-dependent manner and is required for...
7.
Atreya M, Banerjee S, Lautz A, Alder M, Varisco B, Wong H, et al.
EBioMedicine
. 2023 Dec;
99:104938.
PMID: 38142638
Background: Multiple organ dysfunction syndrome (MODS) disproportionately drives morbidity and mortality among critically ill patients. However, we lack a comprehensive understanding of its pathobiology. Identification of genes associated with a...
8.
Wang F, Ting C, Riemondy K, Douglas M, Foster K, Patel N, et al.
J Clin Invest
. 2023 Sep;
133(22).
PMID: 37768734
Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease arising from impaired regeneration of the alveolar epithelium after injury. During regeneration, type 2 alveolar epithelial cells (AEC2s) assume a transitional...
9.
Joshi I, Devine A, Joshi R, Smith N, Varisco B
Sci Rep
. 2023 Sep;
13(1):15259.
PMID: 37709810
Progressive emphysema often leads to end-stage lung disease. Most mouse models of emphysema are typically modest (i.e. cigarette smoke exposure), and changes over time are difficult to quantify. The tracheal...
10.
Devine A, Smith N, Joshi R, Fan Q, Borchers M, Clair G, et al.
Chronic Obstr Pulm Dis
. 2023 Aug;
10(4):380-391.
PMID: 37534975
Chymotrypsin-like elastase 1 (CELA1) is a serine protease that is neutralized by alpha-1antitrypsin (AAT) and prevents emphysema in a murine antisense oligonucleotide model of AAT-deficient emphysema. Mice with genetic ablation...