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Brian M J Foxwell

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Articles 38
Citations 1947
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Recent Articles
1.
Terrando N, Monaco C, Ma D, Foxwell B, Feldmann M, Maze M
Proc Natl Acad Sci U S A . 2010 Nov; 107(47):20518-22. PMID: 21041647
Cognitive decline following surgery in older individuals is a major clinical problem of uncertain mechanism; a similar cognitive decline also follows severe infection, chemotherapy, or trauma and is currently without...
2.
Page T, Turner J, Brown A, Timms E, Inglis J, Brennan F, et al.
J Immunol . 2010 Aug; 185(6):3694-701. PMID: 20713883
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase activity and hence PG production. However, the ability of NSAIDs to ameliorate pain and tenderness does not prevent disease progression in rheumatoid arthritis, a...
3.
Page T, Brown A, Timms E, Foxwell B, Ray K
Arthritis Rheum . 2010 Jul; 62(11):3221-31. PMID: 20589681
Objective: The activity of p38 MAPK regulates lipopolysaccharide (LPS)-stimulated production of key proinflammatory cytokines such as tumor necrosis factor α (TNFα). Consequently, p38 MAPK inhibitors have attracted considerable interest as...
4.
Drexler S, Kong P, Inglis J, Williams R, Garlanda C, Mantovani A, et al.
Arthritis Rheum . 2010 May; 62(8):2249-61. PMID: 20506350
Objective: Single-immunoglobulin interleukin-1 receptor-related (SIGIRR), which is also known as Toll/interleukin-1 receptor 8 (TIR-8), is a member of the TIR domain-containing family of receptors and was first characterized as an...
5.
de Souza J, Okomo U, Alexander N, Aziz N, Owens B, Kaur H, et al.
PLoS One . 2010 Apr; 5(4):e9867. PMID: 20419161
Background: Safe, cheap and effective adjunct therapies preventing the development of, or reducing the mortality from, severe malaria could have considerable and rapid public health impact. Oral activated charcoal (oAC)...
6.
Monaco C, Gregan S, Navin T, Foxwell B, Davies A, Feldmann M
Circulation . 2009 Dec; 120(24):2462-9. PMID: 19948979
Background: Inflammation and matrix degradation are the hallmarks of high-risk atherosclerosis that leads to myocardial infarction and stroke. Toll-like receptors (TLRs), key players in innate immunity, are upregulated in atherosclerotic...
7.
Gasparini C, Foxwell B, Feldmann M
Eur J Immunol . 2009 Aug; 39(8):2215-23. PMID: 19655301
DC, when fully matured are the APC best able to activate naïve T cells. Recently, we demonstrated using adenoviruses overexpressing IkappaBalpha and proteosome inhibitors that NF-kappaB is involved in DC...
8.
Smith A, Rahman F, Hayee B, Graham S, Marks D, Sewell G, et al.
J Exp Med . 2009 Aug; 206(9):1883-97. PMID: 19652016
The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these patients possess an impaired acute inflammatory response, which could result in delayed clearance of bacteria penetrating the lining of...
9.
Thomson S, Goh F, Banks H, Krausgruber T, Kotenko S, Foxwell B, et al.
Proc Natl Acad Sci U S A . 2009 Jul; 106(28):11564-9. PMID: 19570999
IFNs lambda1, lambda2, and lambda3, or type III IFNs, are recently identified cytokines distantly related to type I IFNs. Despite an early evolutionary divergence, the 2 types of IFNs display...
10.
Page T, Smolinska M, Gillespie J, Urbaniak A, Foxwell B
Curr Mol Med . 2009 Feb; 9(1):69-85. PMID: 19199943
The activity of tyrosine kinases is central to many cellular processes, and accumulating evidence suggests that their role in inflammation is no less profound. Three main tyrosine kinase families, the...