Brian K Dieckgraefe
Overview
Explore the profile of Brian K Dieckgraefe including associated specialties, affiliations and a list of published articles.
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37
Citations
1272
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0
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Recent Articles
1.
Subramaniam D, May R, Sureban S, Lee K, George R, Kuppusamy P, et al.
Cancer Res
. 2022 Aug;
82(16):2951.
PMID: 35971679
No abstract available.
2.
Bishnupuri K, Sainathan S, Ciorba M, Houchen C, Dieckgraefe B
Mol Cancer Res
. 2021 Nov;
20(3):387-399.
PMID: 34753802
Implications: These results suggest that pro-proliferative and pro-stemness effects of Reg4 are mediated through γ-secretase-mediated CD44/CD44ICD signaling, hence strategies to disrupt Reg4-CD44-γ-secretase-CD44ICD signaling axis may increase cancer cell susceptibility to...
3.
Sninsky J, Bishnupuri K, Gonzalez I, Trikalinos N, Chen L, Dieckgraefe B
Oncotarget
. 2021 Mar;
12(4):278-291.
PMID: 33659040
Reg4 is highly expressed in gastrointestinal malignancies and acts as a mitogenic and pro-invasive factor. Our recent works suggest that Reg4 binds with CD44 and induces its proteolytic cleavage to...
4.
Fejleh M, Shen C, Chen J, Bushong J, Dieckgraefe B, Sayuk G
JAAPA
. 2020 Mar;
33(4):43-48.
PMID: 32217907
Background: Many communities face a shortage of qualified endoscopists. Training physician assistants (PAs) to perform colonoscopies can expand the availability of colorectal cancer screening. This study examined screening colonoscopy metrics...
5.
Bishnupuri K, Alvarado D, Khouri A, Shabsovich M, Chen B, Dieckgraefe B, et al.
Cancer Res
. 2019 Jan;
79(6):1138-1150.
PMID: 30679179
The tryptophan-metabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) is frequently overexpressed in epithelial-derived malignancies, where it plays a recognized role in promoting tumor immune tolerance. We previously demonstrated that the...
6.
Bishnupuri K, Sainathan S, Bishnupuri K, Leahy D, Luo Q, Anant S, et al.
Mol Carcinog
. 2013 Oct;
53 Suppl 1:E169-80.
PMID: 24151146
Upregulation of regenerating gene 4 (Reg4) is observed in many human gastrointestinal malignancies including colorectal cancer (CRC). We previously reported a Reg4-mediated induction of epidermal growth factor receptor-Akt-AP1 signaling regulating...
7.
Sainathan S, Bishnupuri K, Aden K, Luo Q, Houchen C, Anant S, et al.
Inflamm Bowel Dis
. 2011 Sep;
18(5):955-67.
PMID: 21953855
Background: The pathogenesis of inflammatory bowel disease (IBD) is associated with a dysregulated mucosal immune response. Certain stimulators of innate immunity (CpG DNA or GM-CSF) are reported to be anti-inflammatory...
8.
Subramaniam D, Ramalingam S, Linehan D, Dieckgraefe B, Postier R, Houchen C, et al.
PLoS One
. 2011 Feb;
6(2):e16958.
PMID: 21347286
Background: Curcumin inhibits the growth of pancreatic cancer tumor xenografts in nude mice; however, the mechanism of action is not well understood. It is becoming increasingly clear that RNA binding...
9.
McDonald K, McDonough J, Dieckgraefe B, Newberry R
Am J Pathol
. 2010 Mar;
176(5):2367-77.
PMID: 20304952
In the adult intestine, luminal microbiota induce cryptopatches to transform into isolated lymphoid follicles (ILFs), which subsequently act as sites for the generation of IgA responses. The events leading to...
10.
Hamm C, Reimers M, McCullough C, Gorbe E, Lu J, Gu C, et al.
Inflamm Bowel Dis
. 2010 Feb;
16(10):1649-57.
PMID: 20155851
Background: NOD2 single nucleotide polymorphisms have been associated with increased risk of ileal Crohn's disease (CD). This exploratory study was conducted to compare ileal mucosal gene expression in CD patients...