Brian J Skaggs
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Explore the profile of Brian J Skaggs including associated specialties, affiliations and a list of published articles.
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19
Citations
861
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Recent Articles
1.
McMahon M, Seto R, Skaggs B
Rheumatol Immunol Res
. 2022 Jul;
2(3):157-172.
PMID: 35880242
There is a well-known increased risk for cardiovascular disease that contributes to morbidity and mortality in systemic lupus erythematosus (SLE). Major adverse cardiovascular events and subclinical atherosclerosis are both increased...
2.
Skaggs B, Grossman J, Sahakian L, Perry L, FitzGerald J, Charles-Schoeman C, et al.
ACR Open Rheumatol
. 2021 Feb;
3(4):209-220.
PMID: 33605563
Objective: The increase in cardiovascular events (CVEs) in systemic lupus erythematosus (SLE) is not fully explained by traditional risk factors. We previously identified four biomarkers (proinflammatory high-density lipoprotein, leptin, soluble...
3.
Balbas M, Burgess M, Murali R, Wongvipat J, Skaggs B, Mundel P, et al.
Proc Natl Acad Sci U S A
. 2014 Oct;
111(41):14876-81.
PMID: 25271328
MAGUK Inverted 2 (MAGI-2) is a PTEN-interacting scaffold protein implicated in cancer on the basis of rare, recurrent genomic translocations and deletions in various tumors. In the renal glomerulus, MAGI-2...
4.
Lourenco E, Wong M, Hahn B, Palma-Diaz M, Skaggs B
Arthritis Rheumatol
. 2014 Feb;
66(3):674-85.
PMID: 24574228
Objective: Lupus nephritis depends on autoantibody deposition and activation of multiple immune cell types that promote kidney inflammation, including lymphocytes and monocyte/macrophages. Laquinimod, currently in clinical trials for multiple sclerosis...
5.
McMahon M, Skaggs B, Grossman J, Sahakian L, FitzGerald J, Wong W, et al.
Arthritis Rheumatol
. 2014 Jan;
66(1):130-9.
PMID: 24449580
Objective: An increased frequency of atherosclerosis (ATH) in systemic lupus erythematosus (SLE) is well-documented but not fully explained by the presence of traditional cardiac risk factors. Several nontraditional biomarkers, including...
6.
Skaggs B, Hahn B, McMahon M
Nat Rev Rheumatol
. 2012 Feb;
8(4):214-23.
PMID: 22331061
Rapid-onset cardiovascular disease (CVD) is a major concern for many patients with systemic lupus erythematosus (SLE). Cardiovascular events occur more frequently and with earlier onset in patients with SLE compared...
7.
McMahon M, Skaggs B, Sahakian L, Grossman J, FitzGerald J, Ragavendra N, et al.
Ann Rheum Dis
. 2011 Jun;
70(9):1619-24.
PMID: 21670088
Background: Patients with systemic lupus erythematosus (SLE) are at increased risk of atherosclerosis, even after accounting for traditional risk factors. High levels of leptin and low levels of adiponectin are...
8.
McMahon M, Hahn B, Skaggs B
Expert Rev Clin Immunol
. 2011 Mar;
7(2):227-41.
PMID: 21426260
Patients with systemic lupus erythematosus have a significantly increased risk of cardiovascular events due to atherosclerosis. Traditional cardiac risk factors cannot fully explain this increased risk. Recent evidence strongly suggests...
9.
Skaggs B, Hahn B, Sahakian L, Grossman J, McMahon M
Clin Immunol
. 2010 Jul;
137(1):147-56.
PMID: 20637704
Accelerated atherosclerosis is a major co-morbid condition in autoimmune diseases. Monocytes are the main immune cell involved in atherosclerosis initiation. We hypothesized that dysfunctional, pro-inflammatory HDL (piHDL), which occurs in...
10.
Dinesh R, Skaggs B, La Cava A, Hahn B, Singh R
Autoimmun Rev
. 2010 Apr;
9(8):560-8.
PMID: 20385256
While CD4(+)CD25(high) regulatory T cells (Tregs) have garnered much attention for their role in the maintenance of immune homeostasis, recent findings have shown that subsets of CD8(+) T cells (CD8(+)...