Brian J McHugh
Overview
Explore the profile of Brian J McHugh including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
27
Citations
829
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Rodriguez-Rios M, McHugh B, Liang Z, Megia-Fernandez A, Lilienkampf A, Dockrell D, et al.
Commun Chem
. 2023 Nov;
6(1):237.
PMID: 37919467
Cathepsin D is a protease that is an effector in the immune response of macrophages, yet to date, only a limited number of probes have been developed for its detection....
2.
A mechanistic evaluation of human beta defensin 2 mediated protection of human skin barrier in vitro
Shelley J, McHugh B, Wills J, Dorin J, Weller R, Clarke D, et al.
Sci Rep
. 2023 Feb;
13(1):2271.
PMID: 36755116
The human skin barrier, a biological imperative, is impaired in inflammatory skin diseases such as atopic dermatitis (AD). Staphylococcus aureus is associated with AD lesions and contributes to pathological inflammation...
3.
Ryan E, Sadiku P, Coelho P, Watts E, Zhang A, Howden A, et al.
Am J Respir Crit Care Med
. 2023 Feb;
207(8):998-1011.
PMID: 36724365
Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent airway inflammation and disordered macrophage function. The extent to which alterations in macrophage bioenergetics contribute to impaired antioxidant responses...
4.
Palumbo S, Francfort J, Kakoulides G, McHugh B, McIntyre M
Clin Neurol Neurosurg
. 2022 Nov;
224:107533.
PMID: 36434898
The authors report a case in which an acute thrombosis of a pre-existing arterial stent occurs in a patient's lower extremity during a lumbar spinal fusion surgery. The event was...
5.
Smith K, Minns D, McHugh B, Holloway R, OConnor R, Williams A, et al.
PLoS Biol
. 2022 Aug;
20(8):e3001554.
PMID: 36026478
Multiple sclerosis (MS) is a highly prevalent demyelinating autoimmune condition; the mechanisms regulating its severity and progression are unclear. The IL-17-producing Th17 subset of T cells has been widely implicated...
6.
Humphries D, Mills R, Boz C, McHugh B, Hirani N, Rossi A, et al.
Front Pharmacol
. 2022 Aug;
13:949264.
PMID: 36003515
Galectin-3 (Gal-3) drives fibrosis during chronic lung injury, however, its role in acute lung injury (ALI) remains unknown. Effective pharmacological therapies available for ALI are limited; identifying novel concepts in...
7.
McHugh B, Stephen J, Robb C, Fox S, Kipari T, Cartwright J, et al.
Front Cell Dev Biol
. 2022 Jun;
10:905315.
PMID: 35693926
Cyclin-dependent kinase (CDK) inhibitor drugs (CDKi), such as R-roscovitine and AT7519, induce neutrophil apoptosis and enhance the resolution of inflammation in a number of models. This class of compounds are...
8.
Gwyer Findlay E, Currie A, Zhang A, Ovciarikova J, Young L, Stevens H, et al.
Oncoimmunology
. 2019 Aug;
8(8):1608106.
PMID: 31413918
Immunization of patients with autologous, matured dendritic cell (DC) preparations, in order to prime antitumor T-cell responses, is the focus of intense research. Despite progress and approval of clinical approaches,...
9.
van Boeckel S, Hrabalkova L, Baker T, Macpherson H, Frew L, Boyle A, et al.
Sci Rep
. 2019 May;
9(1):7356.
PMID: 31089176
Preterm birth, defined as delivery before 37 weeks of gestation, is the leading cause of neonatal mortality and morbidity. Infection and inflammation are frequent antecedents of spontaneous preterm birth. Cathelicidin,...
10.
McHugh B, Wang R, Li H, Beaumont P, Kells R, Stevens H, et al.
PLoS Pathog
. 2019 Apr;
15(4):e1007694.
PMID: 30978238
Pulmonary infections are a major global cause of morbidity, exacerbated by an increasing threat from antibiotic-resistant pathogens. In this context, therapeutic interventions aimed at protectively modulating host responses, to enhance...