Brian J Ferguson
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Explore the profile of Brian J Ferguson including associated specialties, affiliations and a list of published articles.
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39
Citations
1104
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Recent Articles
1.
Singh R, Wu Y, Herrero Del Valle A, Leigh K, Mong S, Cheng M, et al.
J Biol Chem
. 2024 Feb;
300(3):105711.
PMID: 38309507
Cytosolic long dsRNA, among the most potent proinflammatory signals, is recognized by melanoma differentiation-associated protein 5 (MDA5). MDA5 binds dsRNA cooperatively forming helical filaments. ATP hydrolysis by MDA5 fulfills a...
2.
Hristova D, Oliveira M, Wagner E, Melcher A, Harrington K, Belot A, et al.
iScience
. 2024 Jan;
27(1):108760.
PMID: 38269102
To mount an efficient interferon response to virus infection, intracellular pattern recognition receptors (PRRs) sense viral nucleic acids and activate anti-viral gene transcription. The mechanisms by which intracellular DNA and...
3.
Teague H, Lefevre C, Rieser E, Wolfram L, de Miguel D, Patricio de Oliveira D, et al.
Cell Death Differ
. 2023 Nov;
31(1):28-39.
PMID: 38001254
The ability of cells to mount an interferon response to virus infections depends on intracellular nucleic acid sensing pattern recognition receptors (PRRs). RIG-I is an intracellular PRR that binds short...
4.
Guabiraba R, Rodrigues D, Manna P, Chollot M, Saint-Martin V, Trapp S, et al.
Dev Comp Immunol
. 2023 Nov;
151:105093.
PMID: 37951324
The innate immune response relies on the ability of host cells to rapidly detect and respond to microbial nucleic acids. Toll-like receptors (TLRs), a class of pattern recognition receptors (PRRs),...
5.
Ricciardi-Jorge T, Lummertz da Rocha E, Gonzalez-Kozlova E, Rodrigues-Luiz G, Ferguson B, Sweeney T, et al.
mBio
. 2023 Sep;
14(5):e0093423.
PMID: 37732809
One of the fundamental features that make viruses intracellular parasites is the necessity to use cellular translational machinery. Hence, this is a crucial checkpoint for controlling infections. Here, we show...
6.
Depierreux D, Smith G, Ferguson B
Front Immunol
. 2023 Mar;
14:1093381.
PMID: 36911702
Natural killer (NK) cells have an established role in controlling poxvirus infection and there is a growing interest to exploit their capabilities in the context of poxvirus-based oncolytic therapy and...
7.
Shmeleva E, Syafiq D, Moldoveanu A, Ferguson B, Smith G
J Gen Virol
. 2023 Feb;
103(11).
PMID: 36748513
Vaccinia virus (VACV) protein N1 is an intracellular immunomodulator that contributes to virus virulence via inhibition of NF-κB. Intradermal infection with a VACV lacking gene (vΔN1) results in smaller skin...
8.
Depierreux D, Altenburg A, Soday L, Fletcher-Etherington A, Antrobus R, Ferguson B, et al.
PLoS Pathog
. 2022 Jun;
18(6):e1010612.
PMID: 35727847
The interaction between immune cells and virus-infected targets involves multiple plasma membrane (PM) proteins. A systematic study of PM protein modulation by vaccinia virus (VACV), the paradigm of host regulation,...
9.
Shmeleva E, Gomez de Aguero M, Wagner J, Enright A, Macpherson A, Ferguson B, et al.
PLoS Pathog
. 2022 Apr;
18(4):e1009854.
PMID: 35446919
Interactions between pathogens, host microbiota and the immune system influence many physiological and pathological processes. In the 20th century, widespread dermal vaccination with vaccinia virus (VACV) led to the eradication...
10.
Wong L, Edgar J, Martello A, Ferguson B, Eden E
Front Cell Dev Biol
. 2021 Apr;
9:640456.
PMID: 33816489
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of the COVID-19 (coronavirus disease 2019) pandemic, is a positive strand RNA (+RNA) virus. Like other +RNA viruses, SARS-CoV-2 is dependent...