Brian J Capaldo
Overview
Explore the profile of Brian J Capaldo including associated specialties, affiliations and a list of published articles.
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16
Citations
468
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Recent Articles
1.
Senatorov I, Bowman J, Jansson K, Alilin A, Capaldo B, Lake R, et al.
Cell Rep Med
. 2024 Dec;
5(12):101868.
PMID: 39657662
Metastatic castrate-resistant prostate cancer (mCRPC) is a genetically and phenotypically heterogeneous cancer where advancements are needed in biomarker discovery and targeted therapy. A critical and often effective component of treatment...
2.
Beshiri M, Capaldo B, Lake R, Ku A, Burner D, Tice C, et al.
Stem Cells
. 2024 Apr;
42(6):526-539.
PMID: 38563224
To resist lineage-dependent therapies such as androgen receptor inhibition, prostate luminal epithelial adenocarcinoma cells often adopt a stem-like state resulting in lineage plasticity and phenotypic heterogeneity. Castrate-resistant prostate adenocarcinoma can...
3.
Agarwal S, Fang L, McGowen K, Yin J, Bowman J, Ku A, et al.
J Clin Invest
. 2023 Sep;
133(22).
PMID: 37725435
Antibody-drug conjugates (ADCs) are a promising targeted cancer therapy; however, patient selection based solely on target antigen expression without consideration for cytotoxic payload vulnerabilities has plateaued clinical benefits. Biomarkers to...
4.
Whitlock N, White M, Capaldo B, Ku A, Agarwal S, Fang L, et al.
Discov Oncol
. 2022 Oct;
13(1):97.
PMID: 36181613
Background: The activities of MYC, the androgen receptor, and its associated pioneer factors demonstrate substantial reprogramming between early and advanced prostate cancer. Although previous studies have shown a shift in...
5.
Einstein D, Arai S, Calagua C, Xie F, Voznesensky O, Capaldo B, et al.
JCO Precis Oncol
. 2021 Sep;
5.
PMID: 34568716
Methods: PC samples spanning one patient's clinical course: diagnostic biopsies, pre- or post-enzalutamide metastatic biopsies, and rapid autopsy samples including a patient-derived xenograft (PDX) were analyzed by targeted exome sequencing...
6.
Wilkinson S, Ye H, Karzai F, Harmon S, Terrigino N, VanderWeele D, et al.
Eur Urol
. 2021 Mar;
80(6):746-757.
PMID: 33785256
Background: Patients diagnosed with high risk localized prostate cancer have variable outcomes following surgery. Trials of intense neoadjuvant androgen deprivation therapy (NADT) have shown lower rates of recurrence among patients...
7.
Whitlock N, Trostel S, Wilkinson S, Terrigino N, Hennigan S, Lake R, et al.
Oncogene
. 2020 Jul;
39(34):5663-5674.
PMID: 32681068
Localized prostate cancer develops very slowly in most men, with the androgen receptor (AR) and MYC transcription factors amongst the most well-characterized drivers of prostate tumorigenesis. Canonically, MYC up-regulation in...
8.
Muehling L, Heymann P, Wright P, Eccles J, Agrawal R, Carper H, et al.
J Allergy Clin Immunol
. 2020 Apr;
146(3):555-570.
PMID: 32320734
Background: Allergic asthmatic subjects are uniquely susceptible to acute wheezing episodes provoked by rhinovirus. However, the underlying immune mechanisms and interaction between rhinovirus and allergy remain enigmatic, and current paradigms...
9.
Balogh P, Adelman E, Pluvinage J, Capaldo B, Freeman K, Singh S, et al.
Haematologica
. 2019 Jun;
105(4):905-913.
PMID: 31171641
Healthy bone marrow progenitors yield a co-ordinated balance of hematopoietic lineages. This balance shifts with aging toward enhanced granulopoiesis with diminished erythropoiesis and lymphopoiesis, changes which likely contribute to the...
10.
Cox K, Commins S, Capaldo B, Workman L, Platts-Mills T, Amir E, et al.
Clin Exp Allergy
. 2018 Dec;
49(5):615-625.
PMID: 30506749
Background: B cells play a critical role in the development and maintenance of food allergy by producing allergen-specific IgE. Despite the importance of B cells in IgE-mediated food allergy, the...