Brian H Northrop
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Explore the profile of Brian H Northrop including associated specialties, affiliations and a list of published articles.
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620
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Recent Articles
1.
Na T, Sander V, Davidson A, Lin R, Hermant Y, Hardie Boys M, et al.
Angew Chem Int Ed Engl
. 2024 Jun;
63(39):e202407764.
PMID: 38932510
Lipopeptides are an important class of biomolecules for drug development. Compared with conventional acylation, a chemoselective lipidation strategy offers a more efficient strategy for late-stage structural derivatisation of a peptide...
2.
Milrod M, Northrop B
Org Biomol Chem
. 2022 Oct;
20(43):8443-8453.
PMID: 36254606
Thermally promoted cycloaddition reactions of tropone-3,4-dimethylester and cyclopentadiene have been investigated using density functional theory calculations at the M06-2X level and the CBS-QB3 method. The reaction shares several characteristics with...
3.
Drogkaris V, Northrop B
Chempluschem
. 2020 Nov;
85(11):2466-2474.
PMID: 33201598
The nucleophile-initiated mechanism of thiol-Michael reactions naturally leads to the formation of undesired nucleophile byproducts. Three aza-Michael compounds representing nucleophile byproducts of thiol-acrylate reactions initiated by 4-dimethylaminopyridine (DMAP), 1-methylimidazole (MIM),...
4.
Savino C, Ryan R, Knee J, Jimenez-Hoyos C, Northrop B
J Phys Chem A
. 2019 Dec;
124(3):529-537.
PMID: 31884788
Aryl boronate esters, such as 2-phenyl-1,3,2-benzodioxaborole (), are important components in the formation of a variety of covalent organic frameworks. The addition of substituents on the aromatic rings of aryl...
5.
Frayne S, Stolz R, Northrop B
Org Biomol Chem
. 2019 Aug;
17(34):7878-7883.
PMID: 31407767
A set of dendrons and dendrimers is synthesized divergently using an orthogonal combination of kinetically-driven thiol-maleimide "click" chemistry and thermodynamically reversible furan-maleimide cycloaddition/retrocycloaddition reactions. Growth is controlled by taking advantage...
6.
Frayne S, Northrop B
J Org Chem
. 2018 Aug;
83(17):10370-10382.
PMID: 30132329
The commonly accepted mechanism of nucleophile-initiated thiol-acrylate reactions requires the formation of undesired nucleophile byproducts. A systematic evaluation of the formation of such nucleophile byproducts has been carried out to...
7.
Frayne S, Murthy R, Northrop B
J Org Chem
. 2017 Jul;
82(15):7946-7956.
PMID: 28695735
Thiol-Michael "click" reactions are essential synthetic tools in the preparation of various materials including polymers, dendrimers, and other macromolecules. Despite increasing efforts to apply thiol-Michael chemistry in a controlled fashion,...
8.
Goldberg A, Northrop B
J Org Chem
. 2016 Jan;
81(3):969-80.
PMID: 26734844
The solution phase self-assembly of boronate esters, diazaboroles, oxathiaboroles, and dithiaboroles from the condensation of arylboronic acids with aromatic diol, diamine, hydroxythiol, and dithiol compounds in chloroform has been investigated...
9.
Choudhary U, Northrop B
Chemistry
. 2013 Dec;
20(4):999-1009.
PMID: 24375683
Five dioxynaphthalene[38]-crown-10 (DNP38C10) macrocycles bearing one, two, three, or four allyl moieties have been synthesized and their ability to spontaneously self-assemble with methyl viologen to form [2]pseudorotaxanes has been evaluated....
10.
Stolz R, Northrop B
J Org Chem
. 2013 Aug;
78(16):8105-16.
PMID: 23924266
A combination of experimental and computational methods has been used to understand the reactivity and selectivity of orthogonal thiol-ene and thiol-yne ″click″ reactions involving N-allyl maleimide (1) and N-propargyl maleimide...