Brian Guth
Overview
Explore the profile of Brian Guth including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
244
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Recent Articles
1.
Vargas H, Rolf M, Wisialowski T, Achanzar W, Bahinski A, Bass A, et al.
Clin Pharmacol Ther
. 2020 Sep;
109(2):310-318.
PMID: 32866317
Defining an appropriate and efficient assessment of drug-induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide....
2.
Rossman E, Cools F, Cordes J, Dhuyvetter D, Doyle J, Friedrichs G, et al.
J Pharmacol Toxicol Methods
. 2020 Jul;
105:106897.
PMID: 32663523
Introduction: Alterations in cardiac contractility can have significant clinical implications, highlighting the need for early detection of potential liabilities. Pre-clinical methods to assess contractility are typically invasive and their translation...
3.
Schmitz S, Tacke S, Guth B, Henke J
PLoS One
. 2017 Mar;
12(3):e0174423.
PMID: 28328950
Repeated anaesthesia may be required in experimental protocols and in daily veterinary practice, but anaesthesia is known to alter physiological parameters in GPs (Cavia porcellus, GPs). This study investigated the...
4.
Pugsley M, Guth B, Chiang A, Doyle J, Engwall M, Guillon J, et al.
J Pharmacol Toxicol Methods
. 2017 Jan;
85:1-21.
PMID: 28065821
Introduction: The importance of drug-induced effects on the inotropic state of the heart is well known. Unlike hemodynamic and cardiac electrophysiological methods, which have been routinely used in drug safety...
5.
Schmitz S, Tacke S, Guth B, Henke J
PLoS One
. 2016 Sep;
11(9):e0161258.
PMID: 27658033
Guinea pigs (GPs) are difficult to anaesthetize successfully, the choices for anaesthesia are limited and physiological parameters are likely to be influenced substantially under anaesthesia. We implanted blood pressure radio-telemetry...
6.
Tseng Y, Linehan B, Ng K, Smith D, Markert M, Patel M, et al.
Int J Pharm
. 2016 Aug;
512(1):137-146.
PMID: 27543349
The aim of this study was to identify an adequate formulation for a poorly soluble lead molecule (BI-A) that would achieve sufficiently high plasma concentrations after oral administration in dogs...
7.
Schmitz S, Henke J, Tacke S, Guth B
J Pharmacol Toxicol Methods
. 2016 Mar;
80:9-18.
PMID: 26992361
Introduction: Guinea pigs (GPs) are a valuable cardiovascular pharmacology model. Implantation of a radio-telemetry system into GPs is, however, challenging and has been associated with a high failure rate in...
8.
Albrecht M, Henke J, Tacke S, Markert M, Guth B
BMC Vet Res
. 2015 Jan;
10:310.
PMID: 25551200
Background: This study evaluated the influence of repeated anaesthesia using isoflurane (ISO, 2-3 Vol%), ketamine-xylazine (KX, 100 mg·kg(-1) + 5 mg·kg(-1), i.m.) or a combination of medetomidine-midazolam-fentanyl (MMF, 0.15 mg·kg(-1) ...
9.
Albrecht M, Henke J, Tacke S, Markert M, Guth B
BMC Vet Res
. 2014 Aug;
10:198.
PMID: 25149627
Background: This study investigated effects on cardiovascular parameters during anaesthesia with isoflurane (ISO, 2-3 Vol%), ketamine-xylazine (KX, 100 mg•kg(-1) + 5 mg•kg(-1)) or a combination of medetomidine-midazolam-fentanyl (MMF, 0.15 mg•kg(-1) ...
10.
Markert M, Trautmann T, Gross M, Ege A, Mayer K, Guth B
J Pharmacol Toxicol Methods
. 2012 May;
66(2):98-105.
PMID: 22554385
Introduction: In order to differentiate heart rate (HR)-induced changes from drug-induced positive or negative inotropic effects, HR-dependent effects need to be taken into account. Left ventricular (LV)dP/dt(max), the maximal value...