Brian E Kalmbach
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Explore the profile of Brian E Kalmbach including associated specialties, affiliations and a list of published articles.
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26
Citations
930
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Recent Articles
1.
Ting J, Johansen N, Kalmbach B, Taskin N, Lee B, Clark J, et al.
Cell Rep
. 2024 Nov;
43(11):114963.
PMID: 39514389
The distinctive physiology of striatal medium spiny neurons (MSNs) underlies their ability to integrate sensory and motor input. In rodents, MSNs have a hyperpolarized resting potential and low input resistance....
2.
Gabitto M, Travaglini K, Rachleff V, Kaplan E, Long B, Ariza J, et al.
Nat Neurosci
. 2024 Oct;
27(12):2366-2383.
PMID: 39402379
Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we...
3.
Dembrow N, Sawchuk S, Dalley R, Opitz-Araya X, Hudson M, Radaelli C, et al.
Cell Rep
. 2024 Sep;
43(9):114718.
PMID: 39277859
Large-scale analysis of single-cell gene expression has revealed transcriptomically defined cell subclasses present throughout the primate neocortex with gene expression profiles that differ depending upon neocortical region. Here, we test...
4.
Mertens E, Leibner Y, Pie J, Galakhova A, Waleboer F, Meijer J, et al.
Cell Rep
. 2024 Apr;
43(4):114100.
PMID: 38607921
Hippocampal pyramidal neuron activity underlies episodic memory and spatial navigation. Although extensively studied in rodents, extremely little is known about human hippocampal pyramidal neurons, even though the human hippocampus underwent...
5.
Gabitto M, Travaglini K, Rachleff V, Kaplan E, Long B, Ariza J, et al.
Res Sq
. 2023 Jun;
PMID: 37292694
Alzheimer's disease (AD) is the most common cause of dementia in older adults. Neuropathological and imaging studies have demonstrated a progressive and stereotyped accumulation of protein aggregates, but the underlying...
6.
Kim M, Radaelli C, Thomsen E, Monet D, Chartrand T, Jorstad N, et al.
Elife
. 2023 May;
12.
PMID: 37249212
Rodent studies have demonstrated that synaptic dynamics from excitatory to inhibitory neuron types are often dependent on the target cell type. However, these target cell-specific properties have not been well...
7.
Brandalise F, Kalmbach B, Cook E, Brager D
J Physiol
. 2023 Jan;
601(4):831-845.
PMID: 36625320
Patients with Fragile X syndrome, the leading monogenetic cause of autism, suffer from impairments related to the prefrontal cortex, including working memory and attention. Synaptic inputs to the distal dendrites...
8.
Bakken T, Jorstad N, Hu Q, Lake B, Tian W, Kalmbach B, et al.
Nature
. 2022 Mar;
604(7904):E8.
PMID: 35319013
No abstract available.
9.
Bakken T, Jorstad N, Hu Q, Lake B, Tian W, Kalmbach B, et al.
Nature
. 2021 Oct;
598(7879):111-119.
PMID: 34616062
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally conserved across mammals. Here, using high-throughput transcriptomic and epigenomic profiling of more than 450,000 single nuclei...
10.
Kalmbach B, Hodge R, Jorstad N, Owen S, de Frates R, Yanny A, et al.
Neuron
. 2021 Sep;
109(18):2914-2927.e5.
PMID: 34534454
In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5) extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of these neurons have been mainly described in rodents, where retrograde...