Brian D Perkins
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Explore the profile of Brian D Perkins including associated specialties, affiliations and a list of published articles.
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44
Citations
761
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Recent Articles
21.
Daniele L, Emran F, Lobo G, Gaivin R, Perkins B
Invest Ophthalmol Vis Sci
. 2016 Jun;
57(7):2942-54.
PMID: 27273592
Purpose: Tail-anchored (TA) proteins contain a single hydrophobic domain at the C-terminus and are posttranslationally inserted into the ER membrane via the GET (guided entry of tail-anchored proteins) pathway. The...
22.
Fogerty J, Denton K, Perkins B
Adv Exp Med Biol
. 2015 Oct;
854:209-15.
PMID: 26427413
The photoreceptor outer segment is a specialized primary cilium, and anchoring of the basal body at the apical membrane is required for outer segment formation. We hypothesized that basal body...
23.
Babino D, Perkins B, Kindermann A, Oberhauser V, von Lintig J
FASEB J
. 2014 Oct;
29(1):216-26.
PMID: 25326538
A cycle of cis-to-trans isomerization of the chromophore is intrinsic to vertebrate vision where rod and cone photoreceptors mediate dim- and bright-light vision, respectively. Daylight illumination can greatly exceed the...
24.
Dicicco R, Bell B, Kaul C, Hollyfield J, Anand-Apte B, Perkins B, et al.
Invest Ophthalmol Vis Sci
. 2014 Sep;
55(10):6281-8.
PMID: 25205862
Purpose: Establish a focal injury/regeneration model in zebrafish using laser photocoagulation guided by optical coherence tomography (OCT). Methods: Adult zebrafish were imaged by OCT and confocal scanning laser ophthalmoscopy (cSLO)...
25.
Krock B, Perkins B
PLoS One
. 2014 Aug;
9(8):e104661.
PMID: 25144710
Specification and development of the apical membrane in epithelial cells requires the function of polarity proteins, including Pard3 and an atypical protein kinase C (PrkC). Many epithelial cells possess microtubule-based...
26.
Wasfy M, Matsui J, Miller J, Dowling J, Perkins B
Exp Eye Res
. 2014 Apr;
122:65-76.
PMID: 24698764
Mutations in myosin VIIa (MYO7A) cause Usher Syndrome 1B (USH1B), a disease characterized by the combination of sensorineural hearing loss and visual impairment termed retinitis pigmentosa (RP). Although the shaker-1...
27.
Ramsey M, Perkins B
J Comp Neurol
. 2012 Nov;
521(8):1803-16.
PMID: 23171982
The asymmetric positioning of basal bodies, and therefore cilia, is often critical for proper cilia function. This planar polarity is critical for motile cilia function but has not been extensively...
28.
Wang H, Chen X, Dudinsky L, Patenia C, Chen Y, Li Y, et al.
Mol Vis
. 2012 Jan;
17:3529-40.
PMID: 22219648
Purpose: Leber congenital amaurosis (LCA) is one of the most severe eye dystrophies characterized by severe vision loss at an early stage and accounts for approximately 5% of all retinal...
29.
Perkins B, Fadool J
Methods Cell Biol
. 2010 Nov;
100:205-18.
PMID: 21111218
In recent years, studies of zebrafish rod and cone photoreceptors have yielded novel insights into the differentiation of distinct photoreceptor cell types and the mechanisms guiding photoreceptor regeneration following cell...
30.
Hudak L, Lunt S, Chang C, Winkler E, Flammer H, Lindsey M, et al.
Invest Ophthalmol Vis Sci
. 2010 Mar;
51(7):3792-9.
PMID: 20207966
PURPOSE. Jeune's asphyxiating thoracic dystrophy (JATD) is an autosomal recessive disorder with symptoms of retinal degeneration, kidney cysts, and chondrodysplasia and results from mutations in the ift80 gene. This study...