Brian D Dynlacht
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Explore the profile of Brian D Dynlacht including associated specialties, affiliations and a list of published articles.
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41
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5045
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Recent Articles
1.
Vitale I, Pietrocola F, Guilbaud E, Aaronson S, Abrams J, Adam D, et al.
Cell Death Differ
. 2023 Apr;
30(5):1097-1154.
PMID: 37100955
Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have...
2.
Shin J, Mir H, Khurram M, Fujihara K, Dynlacht B, Cardozo T, et al.
Nat Metab
. 2023 Feb;
5(2):277-293.
PMID: 36747088
Metabolism is a fundamental cellular process that is coordinated with cell cycle progression. Despite this association, a mechanistic understanding of cell cycle phase-dependent metabolic pathway regulation remains elusive. Here we...
3.
Wang L, Paudyal S, Kang Y, Owa M, Liang F, Spektor A, et al.
Cell Res
. 2021 Nov;
32(2):190-209.
PMID: 34782749
Cytoskeletal networks play an important role in regulating nuclear morphology and ciliogenesis. However, the role of microtubule (MT) post-translational modifications in nuclear shape regulation and cilium disassembly has not been...
4.
Rice J, Weekley B, Kanholm T, Chen Z, Lee S, Fernandez D, et al.
Epigenetics Chromatin
. 2021 May;
14(1):23.
PMID: 34001241
Background: Selective proteolysis of the histone H3 N-terminal tail (H3NT) is frequently observed during eukaryotic development, generating a cleaved histone H3 (H3cl) product within a small, but significant, portion of...
5.
Wang Y, Hou L, Ardehali M, Kingston R, Dynlacht B
J Biol Chem
. 2020 Dec;
296:100170.
PMID: 33298525
Elongin is an RNA polymerase II (RNAPII)-associated factor that has been shown to stimulate transcriptional elongation in vitro. The Elongin complex is thought to be required for transcriptional induction in...
6.
Failler M, Giro-Perafita A, Owa M, Srivastava S, Yun C, Kahler D, et al.
Mol Biol Cell
. 2020 Nov;
32(2):169-185.
PMID: 33206585
We performed a high-throughput whole-genome RNAi screen to identify novel inhibitors of ciliogenesis in normal and basal breast cancer cells. Our screen uncovered a previously undisclosed, extensive network of genes...
7.
Magli A, Baik J, Pota P, Cordero C, Kwak I, Garry D, et al.
Nat Commun
. 2019 May;
10(1):2316.
PMID: 31127120
Chromatin looping allows enhancer-bound regulatory factors to influence transcription. Large domains, referred to as topologically associated domains, participate in genome organization. However, the mechanisms underlining interactions within these domains, which...
8.
Magli A, Baik J, Mills L, Kwak I, Dillon B, Gonzalez R, et al.
PLoS Biol
. 2019 Feb;
17(2):e3000153.
PMID: 30807574
The transcriptional mechanisms driving lineage specification during development are still largely unknown, as the interplay of multiple transcription factors makes it difficult to dissect these molecular events. Using a cell-based...
9.
Wang L, Failler M, Fu W, Dynlacht B
Nat Commun
. 2018 Sep;
9(1):3938.
PMID: 30258116
A long-standing mystery in the centrosome field pertains to the origin of asymmetry within the organelle. The removal of daughter centriole-specific/enriched proteins (DCPs) and acquisition of distal appendages on the...
10.
Wang L, Dynlacht B
Development
. 2018 Sep;
145(18).
PMID: 30224385
The primary cilium is an antenna-like organelle assembled on most types of quiescent and differentiated mammalian cells. This immotile structure is essential for interpreting extracellular signals that regulate growth, development...