Brian D Crompton
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Explore the profile of Brian D Crompton including associated specialties, affiliations and a list of published articles.
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46
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1149
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Recent Articles
11.
Anderson P, Ghisoli M, Crompton B, Klega K, Wexler L, Slotkin E, et al.
Clin Cancer Res
. 2023 Feb;
29(9):1689-1697.
PMID: 36780200
Purpose: Treatment options for recurrent or refractory Ewing's sarcoma (ES) are limited. Vigil is a novel autologous tumor cell therapy expressing bi-shRNA furin/GMCSF plasmid, which previously demonstrated monotherapy activity in...
12.
Abbou S, Klega K, Tsuji J, Tanhaemami M, Hall D, Barkauskas D, et al.
J Clin Oncol
. 2023 Feb;
41(13):2382-2393.
PMID: 36724417
Purpose: Novel biomarkers are needed to differentiate outcomes in intermediate-risk rhabdomyosarcoma (IR RMS). We sought to evaluate strategies for identifying circulating tumor DNA (ctDNA) in IR RMS and to determine...
13.
Dubois S, Krailo M, Glade-Bender J, Buxton A, Laack N, Randall R, et al.
J Clin Oncol
. 2023 Jan;
41(11):2098-2107.
PMID: 36669140
Purpose: Monoclonal antibodies directed against insulin-like growth factor-1 receptor (IGF-1R) have shown activity in patients with relapsed Ewing sarcoma. The primary objective of Children's Oncology Group trial AEWS1221 was to...
14.
Shulman D, Chen S, Hall D, Nag A, Thorner A, Lessnick S, et al.
Br J Cancer
. 2022 Oct;
127(12):2220-2226.
PMID: 36221002
Background: Ewing sarcoma (EWS) is an aggressive sarcoma with no validated molecular biomarkers. We aimed to determine the frequency of STAG2 protein loss by immunohistochemistry (IHC) and whether loss of...
15.
Shulman D, Whittle S, Surdez D, Bailey K, de Alava E, Yustein J, et al.
NPJ Precis Oncol
. 2022 Sep;
6(1):65.
PMID: 36115869
The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients...
16.
Fox V, Spofford I, Crompton B, Yurgelun M, Lillehei C, Goldsmith J
J Pediatr Gastroenterol Nutr
. 2022 Aug;
75(3):e49-e52.
PMID: 35984457
Serrated polyps are pathological neoplastic lesions in the colon with subtle gross morphology leading to underreporting during colonoscopy. While detection rates are increasing in average-risk adult screening colonoscopy, the rate...
17.
Church A, Corson L, Kao P, Imamovic-Tuco A, Reidy D, Doan D, et al.
Nat Med
. 2022 Jun;
28(8):1581-1589.
PMID: 35739269
To evaluate the clinical impact of molecular tumor profiling (MTP) with targeted sequencing panel tests, pediatric patients with extracranial solid tumors were enrolled in a prospective observational cohort study at...
18.
Madanat-Harjuoja L, Renfro L, Klega K, Tornwall B, Thorner A, Nag A, et al.
J Clin Oncol
. 2022 May;
40(26):3047-3056.
PMID: 35580298
Purpose: The utility of circulating tumor DNA (ctDNA) analyses has not been established in the risk stratification of Wilms tumor (WT). We evaluated the detection of ctDNA and selected risk...
19.
Madanat-Harjuoja L, Klega K, Lu Y, Shulman D, Thorner A, Nag A, et al.
Clin Cancer Res
. 2022 May;
28(12):2579-2586.
PMID: 35561344
Purpose: We sought to determine whether the detection of circulating tumor DNA (ctDNA) in samples of patients undergoing chemotherapy for advanced leiomyosarcoma (LMS) is associated with objective response or survival....
20.
Gillani R, Camp S, Han S, Jones J, Chu H, OBrien S, et al.
Am J Hum Genet
. 2022 May;
109(6):1026-1037.
PMID: 35512711
More knowledge is needed regarding germline predisposition to Ewing sarcoma to inform biological investigation and clinical practice. Here, we evaluated the enrichment of pathogenic germline variants in Ewing sarcoma relative...