Brian D Bennett
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Explore the profile of Brian D Bennett including associated specialties, affiliations and a list of published articles.
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33
Citations
896
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Recent Articles
11.
Kinyamu H, Bennett B, Bushel P, Archer T
J Biol Chem
. 2019 Dec;
295(5):1271-1287.
PMID: 31806706
Proteasome activity is required for diverse cellular processes, including transcriptional and epigenetic regulation. However, inhibiting proteasome activity can lead to an increase in transcriptional output that is correlated with enriched...
12.
Sikdar S, Joehanes R, Joubert B, Xu C, Vives-Usano M, Rezwan F, et al.
Epigenomics
. 2019 Sep;
11(13):1487-1500.
PMID: 31536415
Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for exposure in newborns is unknown....
13.
Oldfield A, Henriques T, Kumar D, Burkholder A, Cinghu S, Paulet D, et al.
Nat Commun
. 2019 Jul;
10(1):3072.
PMID: 31296853
Faithful transcription initiation is critical for accurate gene expression, yet the mechanisms underlying specific transcription start site (TSS) selection in mammals remain unclear. Here, we show that the histone-fold domain...
14.
Grimm S, Shimbo T, Takaku M, Thomas J, Auerbach S, Bennett B, et al.
Nat Commun
. 2019 Jan;
10(1):305.
PMID: 30659182
DNA methylation is an essential epigenetic process in mammals, intimately involved in gene regulation. Here we address the extent to which genetics, sex, and pregnancy influence genomic DNA methylation by...
15.
Reese S, Xu C, den Dekker H, Lee M, Sikdar S, Ruiz-Arenas C, et al.
J Allergy Clin Immunol
. 2018 Dec;
143(6):2062-2074.
PMID: 30579849
Background: Epigenetic mechanisms, including methylation, can contribute to childhood asthma. Identifying DNA methylation profiles in asthmatic patients can inform disease pathogenesis. Objective: We sought to identify differential DNA methylation in...
16.
Fu H, Wang L, Wang J, Bennett B, Li J, Zhao B, et al.
Sci Total Environ
. 2018 Sep;
651(Pt 1):1038-1046.
PMID: 30266049
Dioxin and dioxin-related polychlorinated biphenyls are potent toxicants with association with developmental heart defects and congenital heart diseases. However, the underlying mechanism of their developmental toxicity is not fully understood....
17.
Nguyen T, Grimm S, Bushel P, Li J, Li Y, Bennett B, et al.
Nucleic Acids Res
. 2018 Aug;
46(16):8153-8167.
PMID: 30107566
p53 transcriptional networks are well-characterized in many organisms. However, a global understanding of requirements for in vivo p53 interactions with DNA and relationships with transcription across human biological systems in...
18.
Duncan C, Grimm S, Morgan D, Bushel P, Bennett B, Roberts J, et al.
Sci Rep
. 2018 Jul;
8(1):10138.
PMID: 29973619
DNA methylation plays a key role in X-chromosome inactivation (XCI), a process that achieves dosage compensation for X-encoded gene products between mammalian female and male cells. However, differential sex chromosome...
19.
Wan M, Bennett B, Pittman G, Campbell M, Reynolds L, Porter D, et al.
Environ Health Perspect
. 2018 May;
126(4):047015.
PMID: 29706059
Background: Cigarette smoke is a causal factor in cancers and cardiovascular disease. Smoking-associated differentially methylated regions (SM-DMRs) have been observed in disease studies, but the causal link between altered DNA...
20.
Takaku M, Grimm S, Roberts J, Chrysovergis K, Bennett B, Myers P, et al.
Nat Commun
. 2018 Mar;
9(1):1059.
PMID: 29535312
GATA3 is frequently mutated in breast cancer; these mutations are widely presumed to be loss-of function despite a dearth of information regarding their effect on disease course or their mechanistic...