Brian D Athey
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Explore the profile of Brian D Athey including associated specialties, affiliations and a list of published articles.
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45
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927
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Recent Articles
1.
Rajaei F, Minoccheri C, Wittrup E, Wilson R, Athey B, Omenn G, et al.
IEEE/ACM Trans Comput Biol Bioinform
. 2024 Nov;
PP.
PMID: 39504288
Over the past few years, artificial intelligence (AI) has emerged as a transformative force in drug discovery and development (DDD), revolutionizing many aspects of the process. This survey provides a...
2.
Reamaroon N, Sjoding M, Gryak J, Athey B, Najarian K, Derksen H
Comput Biol Med
. 2021 May;
134:104463.
PMID: 33993014
Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury with global prevalence and high mortality. Chest x-rays (CXR) are critical in the early diagnosis and treatment of ARDS. However,...
3.
Kalinin A, Hou X, Ade A, Fon G, Meixner W, Higgins G, et al.
Mol Biol Cell
. 2021 Apr;
32(18):1624-1633.
PMID: 33909457
Histone deacetylase inhibitors, such as valproic acid (VPA), have important clinical therapeutic and cellular reprogramming applications. They induce chromatin reorganization that is associated with altered cellular morphology. However, there is...
4.
Reamaroon N, Sjoding M, Derksen H, Sabeti E, Gryak J, Barbaro R, et al.
BMC Med Imaging
. 2020 Oct;
20(1):116.
PMID: 33059612
Background: This study outlines an image processing algorithm for accurate and consistent lung segmentation in chest radiographs of critically ill adults and children typically obscured by medical equipment. In particular,...
5.
Higgins G, Williams A, Ade A, Alam H, Athey B
Pharmacol Rev
. 2019 Sep;
71(4):520-538.
PMID: 31530573
Chromosome conformation capture methods have revealed the dynamics of genome architecture which is spatially organized into topologically associated domains, with gene regulation mediated by enhancer-promoter pairs in chromatin space. New...
6.
Kalinin A, Allyn-Feuer A, Ade A, Fon G, Meixner W, Dilworth D, et al.
Sci Rep
. 2018 Oct;
8(1):16142.
PMID: 30367081
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
7.
Kalinin A, Allyn-Feuer A, Ade A, Fon G, Meixner W, Dilworth D, et al.
Sci Rep
. 2018 Sep;
8(1):13658.
PMID: 30209281
Quantitative analysis of morphological changes in a cell nucleus is important for the understanding of nuclear architecture and its relationship with pathological conditions such as cancer. However, dimensionality of imaging...
8.
Kalinin A, Higgins G, Reamaroon N, Soroushmehr S, Allyn-Feuer A, Dinov I, et al.
Pharmacogenomics
. 2018 Apr;
19(7):629-650.
PMID: 29697304
This Perspective provides examples of current and future applications of deep learning in pharmacogenomics, including: identification of novel regulatory variants located in noncoding domains of the genome and their function...
9.
Allyn-Feuer A, Ade A, Luzum J, Higgins G, Athey B
Pharmacogenomics
. 2018 Feb;
19(5):413-434.
PMID: 29400612
Aim: 'Pharmacoepigenomics' methods informed by omics datasets and pre-existing knowledge have yielded discoveries in neuropsychiatric pharmacogenomics. Now we evaluate the generality of these methods by discovering an extended warfarin pharmacogenomics...
10.
Higgins G, Allyn-Feuer A, Georgoff P, Nikolian V, Alam H, Athey B
Methods
. 2017 Apr;
123:102-118.
PMID: 28385536
The pharmacoepigenome can be defined as the active, noncoding province of the genome including canonical spatial and temporal regulatory mechanisms of gene regulation that respond to xenobiotic stimuli. Many psychotropic...