Brian Crompton
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Explore the profile of Brian Crompton including associated specialties, affiliations and a list of published articles.
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10
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3112
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Recent Articles
1.
Gupta A, Xue W, Harrison D, Hawkins D, Dasgupta R, Wolden S, et al.
Lancet Oncol
. 2024 Jun;
25(7):912-921.
PMID: 38936378
Background: The Children's Oncology Group defines intermediate-risk rhabdomyosarcoma as unresected FOXO1 fusion-negative disease arising at an unfavourable site or non-metastatic FOXO1 fusion-positive disease. Temsirolimus in combination with chemotherapy has shown...
2.
Murphy A, Cheng C, Williams J, Shaw T, Pinto E, Dieseldorff-Jones K, et al.
Nat Commun
. 2023 Dec;
14(1):8006.
PMID: 38110397
Developing synchronous bilateral Wilms tumor suggests an underlying (epi)genetic predisposition. Here, we evaluate this predisposition in 68 patients using whole exome or genome sequencing (n = 85 tumors from 61...
3.
Campbell K, Posner A, Chen N, Cavanaugh K, Bhushan K, Janeway K, et al.
Pediatr Blood Cancer
. 2023 Sep;
70(12):e30681.
PMID: 37715723
Purpose: Phase 1 study assessing the safety and toxicity of cabozantinib in combination with topotecan and cyclophosphamide for relapsed osteosarcoma and Ewing sarcoma. Methods: Oral cabozantinib (25 mg/m ) was...
4.
Murphy A, Cheng C, Williams J, Shaw T, Pinto E, Dieseldorff-Jones K, et al.
Res Sq
. 2023 Mar;
PMID: 36993649
This study comprehensively evaluated the landscape of genetic and epigenetic events that predispose to synchronous bilateral Wilms tumor (BWT). We performed whole exome or whole genome sequencing, total-strand RNA-seq, and...
5.
Walz A, Maschietto M, Crompton B, Evageliou N, Dix D, Tytgat G, et al.
Pediatr Blood Cancer
. 2023 Jan;
70 Suppl 2:e30130.
PMID: 36592003
The expansion of knowledge regarding driver mutations for Wilms tumor (WT) and malignant rhabdoid tumor of the kidney (MRT) and various translocations for other pediatric renal tumors opens up new...
6.
Hingorani P, Krailo M, Buxton A, Hutson P, Sondel P, Diccianni M, et al.
Eur J Cancer
. 2022 Jul;
172:264-275.
PMID: 35809374
Purpose: Novel effective therapies are urgently needed in recurrent osteosarcoma. GD2 is expressed in human osteosarcoma tumours and cell lines. This study evaluated the disease control rate (DCR) in patients...
7.
Selvanathan S, Graham G, Grego A, Baker T, Hogg J, Simpson M, et al.
Nucleic Acids Res
. 2019 Aug;
47(18):9619-9636.
PMID: 31392992
Connections between epigenetic reprogramming and transcription or splicing create novel mechanistic networks that can be targeted with tailored therapies. Multiple subunits of the chromatin remodeling BAF complex, including ARID1A, play...
8.
Kennedy A, Vallurupalli M, Chen L, Crompton B, Cowley G, Vazquez F, et al.
Oncotarget
. 2015 Sep;
6(30):30178-93.
PMID: 26337082
Ewing sarcoma is an aggressive bone and soft tissue tumor in children and adolescents, with treatment remaining a clinical challenge. This disease is mediated by somatic chromosomal translocations of the...
9.
Lawrence M, Stojanov P, Polak P, Kryukov G, Cibulskis K, Sivachenko A, et al.
Nature
. 2013 Jun;
499(7457):214-218.
PMID: 23770567
Major international projects are underway that are aimed at creating a comprehensive catalogue of all the genes responsible for the initiation and progression of cancer. These studies involve the sequencing...
10.
Borzutzky A, Crompton B, Bergmann A, Giliani S, Baxi S, Martin M, et al.
Clin Immunol
. 2009 Sep;
133(3):287-94.
PMID: 19740703
Hereditary folate malabsorption is a rare inborn error of metabolism due to mutations in the proton-coupled folate transporter (PCFT). Clinical presentation of PCFT deficiency may mimic severe combined immune deficiency...