Brian C Geohagen
Overview
Explore the profile of Brian C Geohagen including associated specialties, affiliations and a list of published articles.
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14
Citations
162
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Recent Articles
1.
Jung G, McDaniel K, LoPachin R, Geohagen B, Smith A, Huffstickler M, et al.
Neurotoxicology
. 2022 Mar;
90:48-61.
PMID: 35227730
Neurotoxicants may be widespread in the environment and can produce serious health impacts in the human population. Screening programs that use in vitro methods have generated data for thousands of...
2.
Melnikov F, Geohagen B, Gavin T, LoPachin R, Anastas P, Coish P, et al.
Neurotoxicology
. 2020 May;
79:95-103.
PMID: 32380191
Xenobiotic electrophiles can form covalent adducts that may impair protein function, damage DNA, and may lead a range of adverse effects. Cumulative neurotoxicity is one adverse effect that has been...
3.
Geohagen B, Weiser D, Loeb D, Nordstroem L, LoPachin R
Chem Biol Interact
. 2020 Jan;
317:108961.
PMID: 31978392
Cisplatin (CisPt) and other platinum (Pt)-based antineoplastic drugs (e.g., carboplatin, oxaliplatin) are highly effective and widely used in the treatment of solid tumors in both pediatric and adult patients. Although...
4.
LoPachin R, Geohagen B, Nordstroem L
Toxicology
. 2019 Mar;
418:62-69.
PMID: 30826385
Electron-deficient chemicals (electrophiles) react with compounds that have one or more unshared valence electron pairs (nucleophiles). The resulting covalent reactions between electrophiles and nucleophiles (e.g., Michael addition, S2 reactions) are...
5.
Geohagen B, Korsharskyy B, Vydyanatha A, Nordstroem L, LoPachin R
Chem Biol Interact
. 2018 Oct;
296:117-123.
PMID: 30287234
Phloretin (Phl) is a dihydrochalcone flavonoid with significant cytoprotective properties; e.g., free radical trapping, electrophile scavenging. Based on this, it has been suggested that Phl might be useful in the...
6.
LoPachin R, Geohagen B, Nordstrom L, Gavin T
Chem Res Toxicol
. 2016 Dec;
29(12):2096-2107.
PMID: 27989140
Evidence from laboratory studies and clinical trials suggests that plant-derived polyphenolic compounds such as curcumin, resveratrol, or phloretin might be useful in the treatment of certain diseases (e.g., Alzheimer's disease)...
7.
Zhang L, Geohagen B, Gavin T, LoPachin R
Chem Biol Interact
. 2016 Jun;
254:198-206.
PMID: 27288850
Human populations are exposed to complex environmental mixtures of acrolein, methylvinyl ketone (MVK) and other type-2 alkenes. Many members of this chemical class are electrophiles that possess a common molecular...
8.
Geohagen B, Vydyanathan A, Kosharskyy B, Shaparin N, Gavin T, LoPachin R
J Pharmacol Exp Ther
. 2016 Apr;
357(3):476-86.
PMID: 27029584
Drug-induced toxicity is often mediated by electrophilic metabolites, such as bioactivation of acetaminophen (APAP) to N-acetyl-p-benzoquinone imine (NAPQI). We have shown that APAP hepatotoxicity can be prevented by 2-acetylcyclopentanone (2-ACP)....
9.
Kosharskyy B, Vydyanathan A, Zhang L, Shaparin N, Geohagen B, Bivin W, et al.
J Pharmacol Exp Ther
. 2015 Feb;
353(1):150-8.
PMID: 25659651
We have previously shown that 2-acetylcyclopentanone (2-ACP), an enolate-forming 1,3-dicarbonyl compound, provides protection in cell culture and animal models of oxidative stress. The pathophysiology of ischemia-reperfusion injury (IRI) involves oxidative...
10.
Zhang L, Gavin T, Geohagen B, Liu Q, Downey K, LoPachin R
J Pharmacol Exp Ther
. 2013 Jun;
346(2):259-69.
PMID: 23759509
Our previous research showed that enolates formed from 1,3-dicarbonyl compounds, such as 2-acetylcyclopentanone (2-ACP), could provide protection in cell culture models from electrophile- or oxidative stress-induced toxicity. In the present...