Brendan J McMorran
Overview
Explore the profile of Brendan J McMorran including associated specialties, affiliations and a list of published articles.
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38
Citations
596
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Recent Articles
11.
Schnider C, Yang H, Starrs L, Ehmann A, Rahimi F, Pierro E, et al.
Front Cell Infect Microbiol
. 2020 Oct;
10:464.
PMID: 33014890
An important component in host resistance to malaria infection are inherited mutations that give rise to abnormalities and deficiencies in erythrocyte proteins and enzymes. Understanding how such mutations confer protection...
12.
Easteal S, Arkell R, Balboa R, Bellingham S, Brown A, Calma T, et al.
Am J Hum Genet
. 2020 Aug;
107(2):175-182.
PMID: 32763188
Expanded carrier screening (ECS) for recessive monogenic diseases requires prior knowledge of genomic variation, including DNA variants that cause disease. The composition of pathogenic variants differs greatly among human populations,...
13.
Ningtyas D, Thomson R, Tarlac V, Nagaraj S, Hoy W, Mathews J, et al.
Front Genet
. 2020 May;
11:432.
PMID: 32425989
The gene encoding protease activated receptor 4 (PAR4) contains a single nucleotide variant, , that is functional. The resulting PAR4 variants, Thr120, and Ala120, are known to differently affect platelet...
14.
Hortle E, Starrs L, Brown F, Jane S, Curtis D, McMorran B, et al.
Sci Rep
. 2020 Feb;
10(1):2303.
PMID: 32024943
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
15.
Hortle E, Starrs L, Brown F, Jane S, Curtis D, McMorran B, et al.
Sci Rep
. 2019 Apr;
9(1):6356.
PMID: 31015511
Plasmodium falciparum malaria causes half a million deaths per year, with up to 9% of this mortality caused by cerebral malaria (CM). One of the major processes contributing to the...
16.
Lawrence N, Dennis A, Lehane A, Ehmann A, Harvey P, Benfield A, et al.
Cell Chem Biol
. 2018 Jul;
25(9):1140-1150.e5.
PMID: 30033131
Malaria is a serious threat to human health and additional classes of antimalarial drugs are greatly needed. The human defense protein, platelet factor 4 (PF4), has intrinsic antiplasmodial activity but...
17.
Kho S, Barber B, Johar E, Andries B, Poespoprodjo J, Kenangalem E, et al.
Blood
. 2018 Jul;
132(12):1332-1344.
PMID: 30026183
Platelets are understood to assist host innate immune responses against infection, although direct evidence of this function in any human disease, including malaria, is unknown. Here we characterized platelet-erythrocyte interactions...
18.
Huang H, McMorran B, Foote S, Burgio G
Mamm Genome
. 2018 Mar;
29(7-8):507-522.
PMID: 29594458
Malaria remains a deadly parasitic disease caused by Plasmodium, claiming almost half a million lives every year. While parasite genetics and biology are often the major targets in many studies,...
19.
Lelliott P, Huang H, Dixon M, Namvar A, Blanch A, Rajagopal V, et al.
Blood Adv
. 2018 Jan;
1(26):2624-2636.
PMID: 29296915
The malaria parasite hijacks host erythrocytes to shield itself from the immune system and proliferate. Red blood cell abnormalities can provide protection from malaria by impeding parasite invasion and growth...
20.
Huang H, Bauer D, Lelliott P, Dixon M, Tilley L, McMorran B, et al.
G3 (Bethesda)
. 2017 Jul;
7(9):3133-3144.
PMID: 28751503
Allelic heterogeneity is a common phenomenon where a gene exhibits a different phenotype depending on the nature of its genetic mutations. In the context of genes affecting malaria susceptibility, it...