Brendan D OFallon
Overview
Explore the profile of Brendan D OFallon including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
9
Citations
130
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Ebbert M, Wadsworth M, Boehme K, Hoyt K, Sharp A, OFallon B, et al.
BMC Bioinformatics
. 2014 Aug;
15 Suppl 7:S12.
PMID: 25080132
Background: Since the advent of next-generation sequencing many previously untestable hypotheses have been realized. Next-generation sequencing has been used for a wide range of studies in diverse fields such as...
2.
OFallon B, Wooderchak-Donahue W, Bayrak-Toydemir P, Crockett D
BMC Bioinformatics
. 2013 Nov;
14 Suppl 13:S1.
PMID: 24268183
Background: Identification of the genetic alterations responsible for human disease is a central challenge facing medical genetics. While many algorithms have been developed to predict the degree of damage caused...
3.
OFallon B, Wooderchak-Donahue W, Crockett D
Bioinformatics
. 2013 Apr;
29(11):1361-6.
PMID: 23620357
Motivation: Accurate determination of single-nucleotide polymorphisms (SNPs) from next-generation sequencing data is a significant challenge facing bioinformatics researchers. Most current methods use mechanistic models that assume nucleotides aligning to a...
4.
OFallon B
BMC Bioinformatics
. 2013 Feb;
14:40.
PMID: 23379678
Background: Reconstruction of population history from genetic data often requires Monte Carlo integration over the genealogy of the samples. Among tools that perform such computations, few are able to consider...
5.
OFallon B, Fehren-Schmitz L
Proc Natl Acad Sci U S A
. 2011 Dec;
108(51):20444-8.
PMID: 22143784
The genetic and demographic impact of European contact with Native Americans has remained unclear despite recent interest. Whereas archeological and historical records indicate that European contact resulted in widespread mortality...
6.
OFallon B
Mol Biol Evol
. 2011 Jun;
28(11):3171-81.
PMID: 21680870
The serial coalescent extends traditional coalescent theory to include genealogies in which not all individuals were sampled at the same time. Inference in this framework is powerful because population size...
7.
OFallon B
Mol Biol Evol
. 2010 Jun;
27(10):2406-16.
PMID: 20513741
Accurate reconstruction of the divergence times among individuals is an essential step toward inferring population parameters from genetic data. However, our ability to reconstruct accurate genealogies is often thwarted by...
8.
OFallon B, Seger J, Adler F
Mol Biol Evol
. 2010 Jan;
27(5):1162-72.
PMID: 20097659
Coalescent theory provides an elegant and powerful method for understanding the shape of gene genealogies and resulting patterns of genetic diversity. However, the coalescent does not naturally accommodate the effects...
9.
OFallon B, Adler F, Proulx S
Proc Biol Sci
. 2007 Oct;
274(1629):3159-64.
PMID: 17939983
Most models of quasi-species evolution predict that populations will evolve to occupy areas of sequence space with the greatest concentration of neutral sequences, thus minimizing the deleterious mutation rate and...