Brenda Faiola
Overview
Explore the profile of Brenda Faiola including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
128
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0
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Recent Articles
1.
Eichenbaum G, Wilsey J, Fessel G, Qiu Q, Perkins L, Hasgall P, et al.
Regul Toxicol Pharmacol
. 2021 Jul;
125:105004.
PMID: 34256083
In 2017, the European Union (EU) Committee for Risk Assessment (RAC) recommended the classification of metallic cobalt (Co) as Category 1B with respect to its carcinogenic and reproductive hazard potential...
2.
Kovochich M, Monnot A, Kougias D, More S, Wilsey J, Qiu Q, et al.
Regul Toxicol Pharmacol
. 2021 Mar;
122:104910.
PMID: 33662479
Cobalt (Co) alloys have been used for over seven decades in a wide range of medical devices, including, but not limited to, hip and knee implants, surgical tools, and vascular...
3.
Cullen J, Faiola B, Melich D, Peterson R, Jordan H, Kimbrough C, et al.
Toxicol Pathol
. 2016 Aug;
44(7):987-97.
PMID: 27519817
Differences in the responses of conventional and germfree male Sprague-Dawley rats to acute injury induced by alpha-naphthylisothiocyanate (ANIT), a well-characterized biliary epithelial toxicant, were evaluated. Conventional and germfree rats were...
4.
Stokes A, Falls J, Yoon L, Cariello N, Faiola B, Colton H, et al.
Int J Toxicol
. 2015 Feb;
34(2):151-61.
PMID: 25722321
Cardiovascular (CV) safety concerns are among the leading causes of compound attrition in drug development. This work describes a strategy of applying novel end points to a 7-day rodent study...
5.
Stokes A, Kemp D, Faiola B, Jordan H, Merrill C, Hailey J, et al.
Int J Toxicol
. 2013 Apr;
32(3):189-97.
PMID: 23616145
When conventional vehicles (eg, methylcellulose and water) impart inadequate physical, chemical, and/or biological properties for proper toxicological assessment of test article formulations, nonconventional vehicles may be considered. Often toxicity data...
6.
Cullen J, Faiola B, Melich D, Peterson R, Jordan H, Kimbrough C, et al.
Toxicol Pathol
. 2012 Aug;
41(1):7-17.
PMID: 22886348
Depletion of Kupffer cells, known to modulate chemical-induced hepatocellular injury, has not been studied with regard to biliary epithelial injury. Here, the authors investigated the effect of Kupffer cell depletion...
7.
Faiola B, Peterson R, Kimbrough C, Jordan H, Cullen J
Toxicol Pathol
. 2010 Jul;
38(5):745-55.
PMID: 20616378
The innate immune response is known to modify hepatocellular injury induced by toxicants. To assess the role of IL-10, a component of the innate immune response, in toxicant-induced injury of...
8.
Cullen J, Falls J, Brown H, Yoon L, Cariello N, Faiola B, et al.
Toxicol Pathol
. 2010 Jun;
38(5):715-29.
PMID: 20551477
Acute toxic responses to a 50-mg/kg oral dose of 1-naphthylisothiocyanate (ANIT) were evaluated by microarray analysis of laser capture-microdissected rat biliary epithelium or hepatic parenchyma obtained 2 and 6 hours...
9.
Faiola B, Falls J, Peterson R, Bordelon N, Brodie T, Cummings C, et al.
Toxicol Sci
. 2008 Jul;
105(2):384-94.
PMID: 18593727
Therapeutic use of certain peroxisome proliferator-activated receptor (PPAR) alpha agonists (fibrates) for the treatment of dyslipidemia has infrequently been associated with the untoward side effect of myopathy. With interest in...
10.
Recio L, Bauer A, Faiola B
Chem Biol Interact
. 2005 Jun;
153-154:159-64.
PMID: 15935812
Benzene induces bone marrow cytotoxicity and chromosomal breaks as a primary mode of action for the induction of bone marrow toxicity. Our research group has used genetically modified mouse models...