Bradley J Undem
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Explore the profile of Bradley J Undem including associated specialties, affiliations and a list of published articles.
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104
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3764
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Recent Articles
1.
Jurcakova D, Ru F, Pecova R, Undem B
Neurosci Lett
. 2024 Nov;
845:138061.
PMID: 39603444
In mammals, many Hymenopteran stings are characterized by pain, redness, and swelling - three manifestations consistent with nociceptive nerve fiber activation. The effect of a Western honeybee (Apis mellifera) venom...
2.
Kim J, Meeker S, Ru F, Tran M, Zabka T, Hackos D, et al.
J Physiol
. 2024 May;
602(14):3505-3518.
PMID: 38743485
Na1.7 plays a crucial role in inducing and conducting action potentials in pain-transducing sensory nociceptor fibres, suggesting that Na1.7 blockers could be effective non-opioid analgesics. While SCN9A is expressed in...
3.
Sun H, Undem B
J Pharmacol Exp Ther
. 2024 Jan;
389(1):118-127.
PMID: 38290975
Heightened excitability of vagal sensory neurons in inflammatory visceral diseases contributes to unproductive and difficult-to-treat neuronally based symptoms such as visceral pain and dysfunction. Identification of targets and modulators capable...
4.
Kim J, Ru F, Meeker S, Undem B
Physiol Rep
. 2023 Dec;
11(24):e15900.
PMID: 38123162
Respiratory viral infection can lead to activation of sensory afferent nerves as indicated by the consequential sore throat, sneezing, coughing, and reflex secretions. In addition to causing troubling symptoms, sensory...
5.
Kim J, Sun H, Meeker S, Undem B
J Physiol
. 2023 Feb;
601(6):1139-1150.
PMID: 36750759
The influence of Na 1.9 on inflammatory mediator-induced activation of airway vagal nodose C-fibres was evaluated by comparing responses in wild-type versus Na 1.9-/- mice. A single-cell RT-PCR analysis indicated...
6.
Patil M, Huang Y, Yu M, Dong X, Undem B, Yu S
Molecules
. 2022 Nov;
27(21).
PMID: 36364288
Chemotherapeutic agent-induced nausea and vomiting are the severe adverse effects that are induced by their stimulations on the peripheral and/or central emetic nerve pathways. Even though ginger has been widely...
7.
Taylor-Clark T, Undem B
Handb Clin Neurol
. 2022 Aug;
188:373-391.
PMID: 35965034
Airway function is under constant neurophysiological control, in order to maximize airflow and gas exchange and to protect the airways from aspiration, damage, and infection. There are multiple sensory nerve...
8.
Sun H, Patil M, Ru F, Meeker S, Undem B
J Physiol
. 2022 Apr;
600(12):2953-2971.
PMID: 35430729
The K 1/D-type potassium current (I ) is an important determinant of neuronal excitability. This study explored whether and how I channels regulate the activation of bronchopulmonary vagal afferent nerves....
9.
Kollarik M, Ru F, Pavelkova N, Mulcahy J, Hunter J, Undem B
Br J Pharmacol
. 2021 Oct;
179(2):242-251.
PMID: 34634134
Background And Purpose: The purpose of this study was to determine the role of Na 1.7 in action potential conduction in C-fibres in the bronchial branches of the human vagus...
10.
Yu M, Chang C, Undem B, Yu S
Molecules
. 2021 Jul;
26(13).
PMID: 34203134
Heartburn and non-cardiac chest pain are the predominant symptoms in many esophageal disorders, such as gastroesophageal reflux disease (GERD), non-erosive reflux disease (NERD), functional heartburn and chest pain, and eosinophilic...