Bradley Downs
Overview
Explore the profile of Bradley Downs including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
12
Citations
269
Followers
0
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Recent Articles
1.
Mamo M, Ye I, DiGiacomo J, Park J, Downs B, Gilkes D
Cancer Res
. 2020 Oct;
80(22):4998-5010.
PMID: 33023947
Intratumoral hypoxia occurs in 90% of solid tumors and is associated with a poor prognosis for patients. Cancer cells respond to hypoxic microenvironments by activating the transcription factors, hypoxia-inducible factor...
2.
Gilpatrick T, Lee I, Graham J, Raimondeau E, Bowen R, Heron A, et al.
Nat Biotechnol
. 2020 Feb;
38(4):433-438.
PMID: 32042167
Despite recent improvements in sequencing methods, there remains a need for assays that provide high sequencing depth and comprehensive variant detection. Current methods are limited by the loss of native...
3.
Downs B, Sherman S, Cui J, Kim Y, Snyder C, Christensen M, et al.
Eur J Cancer
. 2018 Dec;
107:68-78.
PMID: 30551077
Purpose: The presence of pathogenic germline mutation in BRCA1 gene is considered as the most penetrant genetic predisposition for breast cancer. However, a portion of BRCA1 mutation carriers never develops...
4.
Downs B, Xiao F, Kim Y, Chen P, Huang D, Fleissner E, et al.
Breast J
. 2017 Jan;
23(4):479-481.
PMID: 28117528
No abstract available.
5.
Kim Y, Cui J, Luo J, Xiao F, Downs B, Wang S
Sci Rep
. 2016 Jul;
6:30716.
PMID: 27464681
Core promoter controls the initiation of transcription. Core promoter sequence change can disrupt transcriptional regulation, lead to impairment of gene expression and ultimately diseases. Therefore, comprehensive characterization of core promoters...
6.
Cui J, Luo J, Kim Y, Snyder C, Becirovic D, Downs B, et al.
Front Oncol
. 2016 May;
6:92.
PMID: 27148484
Ku80 is a subunit of the Ku heterodimer that binds to DNA double-strand break ends as part of the non-homologous end joining (NHEJ) pathway. Ku80 is also involved in homologous...
7.
Kim Y, Zhao L, Zhang H, Huang Y, Cui J, Xiao F, et al.
Oncotarget
. 2016 Feb;
7(8):9600-12.
PMID: 26848529
Germline mutations in BRCA1 and BRCA2 are the most penetrating genetic predispositions for breast and ovarian cancer, and their presence is largely ethnic-specific. Comprehensive information about the prevalence and spectrum...
8.
Angulo-Ibanez M, Rovira-Clave X, Granados-Jaen A, Downs B, Kim Y, Wang S, et al.
Cell Cycle
. 2015 Dec;
14(24):3864-76.
PMID: 26697837
An adequate supply of nucleotides is essential for accurate DNA replication, and inappropriate deoxyribonucleotide triphosphate (dNTP) concentrations can lead to replication stress, a common source of DNA damage, genomic instability...
9.
Downs B, Kim Y, Xiao F, Snyder C, Chen P, Fleissner E, et al.
Breast Cancer Res Treat
. 2015 Apr;
151(1):219-24.
PMID: 25833210
Partner and localizer of BRCA2 (PALB2), plays an important functional role in DNA damage repair. Recent studies indicate that germline mutations in PALB2 predispose individuals to a high risk of...
10.
Downs B, Wang S
Cancer Genet
. 2015 Mar;
208(5):237-40.
PMID: 25800897
Familial breast cancer occurs in about 10% of breast cancer cases. Germline mutation in BRCA1 is the most penetrant predisposition for the disease. Mutated BRCA1 leads to disease by causing...