Brad L Lackford
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Explore the profile of Brad L Lackford including associated specialties, affiliations and a list of published articles.
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4
Citations
102
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Recent Articles
1.
Chen Q, Malki S, Xu X, Bennett B, Lackford B, Kirsanov O, et al.
bioRxiv
. 2023 Oct;
PMID: 37873304
The foundation of spermatogenesis and lifelong fertility is provided by spermatogonial stem cells (SSCs). SSCs divide asymmetrically to either replenish their numbers (self-renewal) or produce undifferentiated progenitors that proliferate before...
2.
Cinghu S, Yellaboina S, Freudenberg J, Ghosh S, Zheng X, Oldfield A, et al.
Proc Natl Acad Sci U S A
. 2014 Apr;
111(16):E1581-90.
PMID: 24711389
Identification of genes associated with specific biological phenotypes is a fundamental step toward understanding the molecular basis underlying development and pathogenesis. Although RNAi-based high-throughput screens are routinely used for this...
3.
Zheng X, Dumitru R, Lackford B, Freudenberg J, Singh A, Archer T, et al.
Stem Cells
. 2012 Feb;
30(5):910-22.
PMID: 22367759
Embryonic stem cell (ESC) identity and self-renewal is maintained by extrinsic signaling pathways and intrinsic gene regulatory networks. Here, we show that three members of the Ccr4-Not complex, Cnot1, Cnot2,...
4.
Freudenberg J, Ghosh S, Lackford B, Yellaboina S, Zheng X, Li R, et al.
Nucleic Acids Res
. 2012 Jan;
40(8):3364-77.
PMID: 22210859
The TET family of FE(II) and 2-oxoglutarate-dependent enzymes (Tet1/2/3) promote DNA demethylation by converting 5-methylcytosine to 5-hydroxymethylcytosine (5hmC), which they further oxidize into 5-formylcytosine and 5-carboxylcytosine. Tet1 is robustly expressed...