Boudewijn P T Kruithof
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Explore the profile of Boudewijn P T Kruithof including associated specialties, affiliations and a list of published articles.
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29
Citations
569
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Recent Articles
1.
Rodrigues Sousa E, de Brot S, Zoni E, Zeinali S, Brunello A, Scarpa M, et al.
Oncogene
. 2024 Nov;
44(7):462-475.
PMID: 39592836
CRIPTO (or CR-1 or TDGF1) is a protein that plays an active role in tumor initiation and progression. We have confirmed that increased expression of CRIPTO is associated with clinical...
2.
Kruithof B, Mousavi Gourabi B, van de Merbel A, DeRuiter M, Goumans M
JACC Basic Transl Sci
. 2024 Sep;
9(8):1005-1022.
PMID: 39297130
Fibrosis is a characteristic of many cardiac diseases for which no effective treatment exists. We have developed an ex vivo flow system, which allows induction of cardiac fibrosis in intact...
3.
Zhang J, van Dinther M, Thorikay M, Mousavi Gourabi B, Kruithof B, Ten Dijke P
Cell Mol Life Sci
. 2023 Jan;
80(2):43.
PMID: 36646950
Ubiquitin-specific protease (USP)19 is a deubiquitinating enzyme that regulates the stability and function of multiple proteins, thereby controlling various biological responses. The alternative splicing of USP19 results in the expression...
4.
Karkampouna S, van der Helm D, Scarpa M, van Hoek B, Verspaget H, Goumans M, et al.
Cells
. 2021 Dec;
10(12).
PMID: 34943832
Oncofetal protein, CRIPTO, is silenced during homeostatic postnatal life and often re-expressed in different neoplastic processes, such as hepatocellular carcinoma. Given the reactivation of CRIPTO in pathological conditions reported in...
5.
Kruithof B, van Wijngaarden A, Mousavi Gourabi B, Hjortnaes J, Palmen M, Ajmone Marsan N
J Cardiovasc Dev Dis
. 2021 Aug;
8(7).
PMID: 34357322
The formation of superimposed tissue (SIT), a layer on top of the original valve leaflet, has been described in patients with mitral regurgitation as a major contributor to valve thickening...
6.
Kruithof B, van de Pol V, Los T, Lodder K, Mousavi Gourabi B, DeRuiter M, et al.
J Mol Cell Cardiol
. 2021 Mar;
156:95-104.
PMID: 33744308
Calcific aortic valve disease (CAVD) is a common progressive disease of the aortic valves, for which no medical treatment exists and surgery represents currently the only therapeutic solution. The development...
7.
van Wijngaarden A, Kruithof B, Vinella T, Barge-Schaapveld D, Ajmone Marsan N
J Cardiovasc Dev Dis
. 2021 Mar;
8(2).
PMID: 33671724
Degenerative mitral valve disease causing mitral valve prolapse is the most common cause of primary mitral regurgitation, with two distinct phenotypes generally recognized with some major differences, i.e., fibroelastic deficiency...
8.
Kruithof B, Paardekooper L, Hiemstra Y, Goumans M, Palmen M, Delgado V, et al.
Cardiovasc Res
. 2019 Sep;
116(5):931-943.
PMID: 31497851
Aims: In mitral valve prolapse (MVP), leaflet thickening has recently been suggested to be due, in addition to a myxomatous degeneration, to the presence of a superimposed tissue (SIT), defined...
9.
Bax N, Duim S, Kruithof B, Smits A, Bouten C, Goumans M
Front Cardiovasc Med
. 2019 Jul;
6:81.
PMID: 31275946
Human epicardium-derived cells (hEPDCs) transplanted in the NOD-SCID mouse heart after myocardial infarction (MI) are known to improve cardiac function, most likely orchestrated by paracrine mechanisms that limit adverse remodeling....
10.
Alkema M, Goumans M, Kruithof B
Methods Mol Biol
. 2018 Nov;
1891:191-200.
PMID: 30414134
Immunohistochemistry allows the detection of the presence, localization, and activation of proteins in biological tissues by using the ability of antibodies to bind to specific antigens. Cellular signaling can be...