Borja L Holgado
Overview
Explore the profile of Borja L Holgado including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
979
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0
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Recent Articles
1.
Fan J, Erickson A, Carrillo-Garcia J, Wang X, Skowron P, Wang X, et al.
Dev Cell
. 2025 Jan;
PMID: 39862856
Distinguishing tumor maintenance genes from initiation, progression, and passenger genes is critical for developing effective therapies. We employed a functional genomic approach using the Lazy Piggy transposon to identify tumor...
2.
Donovan L, Delaidelli A, Joseph S, Bielamowicz K, Fousek K, Holgado B, et al.
Nat Med
. 2021 May;
27(6):1117-1120.
PMID: 34045740
No abstract available.
3.
Skowron P, Farooq H, Cavalli F, Morrissy A, Ly M, Hendrikse L, et al.
Nat Commun
. 2021 Mar;
12(1):1749.
PMID: 33741928
Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort...
4.
Michealraj K, Kumar S, Kim L, Cavalli F, Przelicki D, Wojcik J, et al.
Cell
. 2020 May;
181(6):1329-1345.e24.
PMID: 32445698
Posterior fossa A (PFA) ependymomas are lethal malignancies of the hindbrain in infants and toddlers. Lacking highly recurrent somatic mutations, PFA ependymomas are proposed to be epigenetically driven tumors for...
5.
Donovan L, Delaidelli A, Joseph S, Bielamowicz K, Fousek K, Holgado B, et al.
Nat Med
. 2020 Apr;
26(5):720-731.
PMID: 32341580
Recurrent medulloblastoma and ependymoma are universally lethal, with no approved targeted therapies and few candidates presently under clinical evaluation. Nearly all recurrent medulloblastomas and posterior fossa group A (PFA) ependymomas...
6.
Van Ommeren R, Garzia L, Holgado B, Ramaswamy V, Taylor M
Brain Pathol
. 2019 Dec;
30(3):691-702.
PMID: 31883407
Medulloblastoma (MB) is the most common primary malignant brain tumor of childhood and a significant contributor to pediatric morbidity and death. While metastatic dissemination is the predominant cause of morbidity...
7.
Vladoiu M, El-Hamamy I, Donovan L, Farooq H, Holgado B, Sundaravadanam Y, et al.
Nature
. 2019 May;
572(7767):67-73.
PMID: 31043743
Study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. Here we use...
8.
Garzia L, Kijima N, Morrissy A, De Antonellis P, Guerreiro-Stucklin A, Holgado B, et al.
Cell
. 2018 Jun;
173(6):1549.
PMID: 29856958
No abstract available.
9.
Garzia L, Kijima N, Morrissy A, De Antonellis P, Guerreiro-Stucklin A, Holgado B, et al.
Cell
. 2018 Feb;
172(5):1050-1062.e14.
PMID: 29474906
While the preponderance of morbidity and mortality in medulloblastoma patients are due to metastatic disease, most research focuses on the primary tumor due to a dearth of metastatic tissue samples...
10.
Mack S, Pajtler K, Chavez L, Okonechnikov K, Bertrand K, Wang X, et al.
Nature
. 2017 Dec;
553(7686):101-105.
PMID: 29258295
Genomic sequencing has driven precision-based oncology therapy; however, the genetic drivers of many malignancies remain unknown or non-targetable, so alternative approaches to the identification of therapeutic leads are necessary. Ependymomas...