Borhane Guezguez
Overview
Explore the profile of Borhane Guezguez including associated specialties, affiliations and a list of published articles.
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Articles
24
Citations
314
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0
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Recent Articles
11.
Guezguez B, Almakadi M, Benoit Y, Shapovalova Z, Rahmig S, Fiebig-Comyn A, et al.
Cancer Cell
. 2016 Jan;
29(1):61-74.
PMID: 26766591
Initial pathway alternations required for pathogenesis of human acute myeloid leukemia (AML) are poorly understood. Here we reveal that removal of glycogen synthase kinase-3α (GSK-3α) and GSK-3β dependency leads to...
12.
Dingwall S, Lee J, Guezguez B, Fiebig A, McNicol J, Boreham D, et al.
Oncotarget
. 2015 Jun;
6(26):22258-69.
PMID: 26082437
Studies have implicated that a small sub-population of cells within a tumour, termed cancer stem cells (CSCs), have an enhanced capacity for tumour formation in multiple cancers and may be...
13.
Kushwah R, Guezguez B, Lee J, Hopkins C, Bhatia M
EMBO Rep
. 2014 Sep;
15(11):1128-38.
PMID: 25252682
The Notch signaling pathway is evolutionarily conserved across species and plays an important role in regulating cell differentiation, proliferation, and survival. It has been implicated in several different hematopoietic processes...
14.
Benoit Y, Guezguez B, Boyd A, Bhatia M
Clin Cancer Res
. 2014 Jul;
20(21):5372-8.
PMID: 25006223
Aberrant regulation of the canonical Wnt signaling pathway (Wnt-β-catenin-GSK3 axis) has been a prevalent theme in cancer biology since earlier observations until recent genetic discoveries gleaned from tumor genome sequencing....
15.
16.
McIntyre B, Alev C, Mechael R, Salci K, Lee J, Fiebig-Comyn A, et al.
Stem Cells Transl Med
. 2013 Dec;
3(1):7-17.
PMID: 24300555
Production of human embryonic stem cell (hESC)-derived lung progenitors has broad applicability for drug screening and cell therapy; however, this is complicated by limitations in demarcating phenotypic changes with functional...
17.
Guezguez B, Campbell C, Boyd A, Karanu F, Casado F, Cresce C, et al.
Cell Stem Cell
. 2013 Aug;
13(2):175-89.
PMID: 23910084
Numerous studies have shown that the bone marrow (BM) niche plays a key role in mouse hematopoietic stem cell (HSC) function and involves contributions from a broad array of cell...
18.
Schnerch A, Lee J, Graham M, Guezguez B, Bhatia M
Stem Cells Dev
. 2012 Jul;
22(1):73-89.
PMID: 22800282
Hematopoietic cells derived from human embryonic stem cells (hESCs) have a number of potential utilities, including the modeling of hematological disorders in vitro, whereas the use for cell replacement therapies...
19.
Trowbridge J, Guezguez B, Moon R, Bhatia M
Stem Cells
. 2010 Jun;
28(8):1379-89.
PMID: 20521329
Quiescent cells lacking expression of mature lineage makers and the c-Kit receptor reside in adult bone marrow. Despite their phenotypic similarity to hematopoietic stem cells, these Lin(-)Sca-1(+)c-Kit(-) cells lack myeloid...
20.
Guezguez B, Bhatia M
Curr Opin Organ Transplant
. 2008 Jul;
13(1):44-52.
PMID: 18660706
Purpose Of Review: Some of the common clinical applications of hematopoietic stem cell (HSC) transplantation are used for treatment of leukemic malignancies, bone marrow/hematopoietic failure, and immunodeficiencies. Several inherent limitations...