Borhane Guezguez
Overview
Explore the profile of Borhane Guezguez including associated specialties, affiliations and a list of published articles.
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24
Citations
314
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Recent Articles
1.
Shah V, Giotopoulos G, Osaki H, Meyerhofer M, Meduri E, Gallego-Crespo A, et al.
Blood
. 2024 Dec;
145(7):748-764.
PMID: 39651888
Initial clinical trials with drugs targeting epigenetic modulators, such as bromodomain and extraterminal protein (BET) inhibitors, demonstrate modest results in acute myeloid leukemia (AML). A major reason for this involves...
2.
Prummel K, Woods K, Kholmatov M, Schmitt E, Vlachou E, Poschmann G, et al.
bioRxiv
. 2024 Dec;
PMID: 39651275
Somatic mutations in hematopoietic stem/progenitor cells (HSPCs) can lead to clonal hematopoiesis of indeterminate potential (CHIP), potentially progressing to myelodysplastic syndromes (MDS). Here, we investigated how CHIP and MDS remodel...
3.
Beier A, Ebersbach C, Siciliano T, Scholze J, Hofmann J, Honscheid P, et al.
Oncogene
. 2024 May;
43(26):2038-2050.
PMID: 38750263
Docetaxel (DX) serves as a palliative treatment option for metastatic prostate cancer (PCa). Despite initial remission, acquired DX resistance is inevitable. The mechanisms behind DX resistance have not yet been...
4.
Winter S, Gotze K, Hecker J, Metzeler K, Guezguez B, Woods K, et al.
Leukemia
. 2024 Mar;
38(5):936-946.
PMID: 38514772
Clonal hematopoiesis (CH) defines a premalignant state predominantly found in older persons that increases the risk of developing hematologic malignancies and age-related inflammatory diseases. However, the risk for malignant transformation...
5.
Sohl J, Hartmann A, Hahlbrock J, Bartneck J, Stassen M, Klein M, et al.
NPJ Vaccines
. 2023 Jun;
8(1):94.
PMID: 37349361
No abstract available.
6.
Sohl J, Hartmann A, Hahlbrock J, Bartneck J, Stassen M, Klein M, et al.
NPJ Vaccines
. 2022 Sep;
7(1):112.
PMID: 36153349
Transcutaneous immunization (TCI) utilizing the TLR7 agonist imiquimod (IMQ-TCI) induces T cell-driven protective immunity upon application onto intact skin. In our present work, we combine the anti-psoriatic agent dithranol with...
7.
Woods K, Guezguez B
Front Cell Dev Biol
. 2021 Aug;
9:714716.
PMID: 34447754
Mesenchymal stromal cells (MSCs) are a heterogenous cell population found in a wide range of tissues in the body, known for their nutrient-producing and immunomodulatory functions. In the bone marrow...
8.
Sasca D, Guezguez B, Kuhn M
Curr Opin Hematol
. 2021 Jul;
28(5):356-363.
PMID: 34267079
Purpose Of Review: Comprehensive sequencing studies aimed at determining the genetic landscape of myeloid neoplasms have identified epigenetic regulators to be among the most commonly mutated genes. Detailed studies have...
9.
10.
Legscha K, Antunes Ferreira E, Chamoun A, Lang A, Awwad M, Ton G, et al.
J Immunother Cancer
. 2021 Jun;
9(6).
PMID: 34112738
Background: Tumor microenvironment-associated T cell senescence is a key limiting factor for durable effective cancer immunotherapy. A few studies have demonstrated the critical role of the tumor suppressor TP53-derived p53...