Bon Ham Yip
Overview
Explore the profile of Bon Ham Yip including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
430
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0
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Recent Articles
11.
Valletta S, Dolatshad H, Bartenstein M, Yip B, Bello E, Gordon S, et al.
Oncotarget
. 2015 Dec;
6(42):44061-71.
PMID: 26623729
Recurrent somatic mutations of the epigenetic modifier and tumor suppressor ASXL1 are common in myeloid malignancies, including chronic myeloid leukemia (CML), and are associated with poor clinical outcome. CRISPR/Cas9 has...
12.
Pellagatti A, Dolatshad H, Yip B, Valletta S, Boultwood J
Adv Biol Regul
. 2015 Oct;
60:122-134.
PMID: 26433620
Genome editing technologies have advanced significantly over the past few years, providing a fast and effective tool to precisely manipulate the genome at specific locations. The three commonly used genome...
13.
Boultwood J, Dolatshad H, Varanasi S, Yip B, Pellagatti A
Adv Biol Regul
. 2013 Oct;
54:153-61.
PMID: 24080589
Accurate pre-mRNA splicing by the spliceosome is a fundamental cellular mechanism required to remove introns that are present in most protein-coding transcripts. The recent discovery of a variety of somatic...
14.
Caceres G, McGraw K, Yip B, Pellagatti A, Johnson J, Zhang L, et al.
Proc Natl Acad Sci U S A
. 2013 Sep;
110(40):16127-32.
PMID: 24043769
Stabilization of p53 in erythroid precursors in response to nucleosomal stress underlies the hypoplastic anemia in myelodysplastic syndromes (MDS) with chromosome 5q deletion [del(5q)]. We investigated whether cenersen, a clinically...
15.
Yip B, So C
Exp Biol Med (Maywood)
. 2013 Apr;
238(3):315-23.
PMID: 23598978
Transcription factors critical for normal hematopoietic stem cell functions are frequently mutated in acute leukemia leading to an aberrant re-programming of normal hematopoietic progenitor/stem cells into leukemic stem cells. Among...
16.
Davies C, Yip B, Fernandez-Mercado M, Woll P, Agirre X, Prosper F, et al.
Br J Haematol
. 2013 Jan;
160(6):842-50.
PMID: 23294243
The ASXL1 gene encodes a chromatin-binding protein involved in epigenetic regulation in haematopoietic cells. Loss-of-function ASXL1 mutations occur in patients with a range of myeloid malignancies and are associated with...
17.
Boultwood J, Yip B, Vuppusetty C, Pellagatti A, Wainscoat J
Adv Biol Regul
. 2012 Oct;
53(1):8-17.
PMID: 23031788
Patients with the 5q- syndrome and Diamond-Blackfan anemia (DBA) suffer from a severe macrocytic anemia. The 5q- syndrome and DBA are disorders of aberrant ribosome biogenesis (ribosomopathies) and haploinsufficiency of...
18.
Fernandez-Mercado M, Yip B, Pellagatti A, Davies C, Larrayoz M, Kondo T, et al.
PLoS One
. 2012 Aug;
7(8):e42334.
PMID: 22912701
Acute myeloid leukemia patients with normal cytogenetics (CN-AML) account for almost half of AML cases. We aimed to study the frequency and relationship of a wide range of genes previously...