Bogdan Pasaniuc
Overview
Explore the profile of Bogdan Pasaniuc including associated specialties, affiliations and a list of published articles.
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175
Citations
9702
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Recent Articles
1.
Jin J, Li B, Wang X, Yang X, Li Y, Wang R, et al.
medRxiv
. 2025 Feb;
PMID: 39990574
Polygenic risk scores (PRS) are becoming increasingly vital for risk prediction and stratification in precision medicine. However, PRS model training presents significant challenges for broader adoption of PRS, including limited...
2.
Yamaguchi T, Houlahan K, Zhu H, Kurganovs N, Livingstone J, Fox N, et al.
Cancer Discov
. 2025 Feb;
PMID: 39945744
Newly diagnosed prostate cancers differ dramatically in mutational composition and lethality. The most accurate clinical predictor of lethality is tumor tissue architecture, quantified as tumor grade. To interrogate the evolutionary...
3.
De La Vega F, Barnes K, Bland H, Edwards T, Fox K, Ioannidis A, et al.
Pac Symp Biocomput
. 2024 Dec;
30:247-250.
PMID: 39670374
The following sections are included: Overview, Advancing multi-ancestry genetic research, Integrating social determinants of health to enhance genetic risk models, Methods to detect and mitigate disparities, Addressing Disparities in Adverse...
4.
Chang Y, Head S, Harrison T, Yu Y, Huff C, Pasaniuc B, et al.
medRxiv
. 2024 Nov;
PMID: 39574839
Integrating genome-wide association study (GWAS) and transcriptomic datasets can help identify potential mediators for germline genetic risk of cancer. However, traditional methods have been largely unsuccessful because of an overreliance...
5.
Abramowitz S, Boulier K, Keat K, Cardone K, Shivakumar M, DePaolo J, et al.
JAMA
. 2024 Nov;
333(1):60-70.
PMID: 39549270
Importance: Polygenic risk scores (PRSs) for coronary heart disease (CHD) are a growing clinical and commercial reality. Whether existing scores provide similar individual-level assessments of disease susceptibility remains incompletely characterized....
6.
Doyle A, Bearden C, Gur R, Ledbetter D, Martin C, McCoy Jr T, et al.
Biol Psychiatry
. 2024 Oct;
97(5):450-460.
PMID: 39424167
Genome-wide studies are yielding a growing catalog of common and rare variants that confer risk for psychopathology. However, despite representing unprecedented progress, emerging data also indicate that the full promise...
7.
Heffel M, Zhou J, Zhang Y, Lee D, Hou K, Pastor-Alonso O, et al.
Nature
. 2024 Oct;
635(8038):481-489.
PMID: 39385032
The human hippocampus and prefrontal cortex play critical roles in learning and cognition, yet the dynamic molecular characteristics of their development remain enigmatic. Here we investigated the epigenomic and three-dimensional...
8.
German J, Cordioli M, Tozzo V, Urbut S, Arumae K, Smit R, et al.
medRxiv
. 2024 Sep;
PMID: 39314946
Obesity is a significant public health concern. GLP-1 receptor agonists (GLP1-RA), predominantly in use as a type 2 diabetes treatment, are a promising pharmacological approach for weight loss, while bariatric...
9.
He Y, Lu W, Jee Y, Wang Y, Tsuo K, Qian D, et al.
medRxiv
. 2024 Sep;
PMID: 39252935
While respiratory diseases such as COPD and asthma share many risk factors, most studies investigate them in insolation and in predominantly European ancestry populations. Here, we conducted the most powerful...
10.
Fu M, Valiente-Banuet L, Wadhwa S, Pasaniuc B, Vossel K, Chang T
Commun Biol
. 2024 Aug;
7(1):1049.
PMID: 39183196
Genetic risk modeling for dementia offers significant benefits, but studies based on real-world data, particularly for underrepresented populations, are limited. We employ an Elastic Net model for dementia risk prediction...