Blake A Caldwell
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Explore the profile of Blake A Caldwell including associated specialties, affiliations and a list of published articles.
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10
Citations
40
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Recent Articles
1.
Caldwell B, Ie S, Lucas A, Li L
Sci Rep
. 2025 Jan;
15(1):2059.
PMID: 39814939
Sepsis is a leading cause of death worldwide, with most patient mortality stemming from lingering immunosuppression in sepsis survivors. This is due in part to immune dysfunction resulting from monocyte...
2.
Geng S, Lu R, Zhang Y, Wu Y, Xie L, Caldwell B, et al.
Circ Res
. 2024 Sep;
135(8):856-872.
PMID: 39224974
Background: Chronic inflammation initiated by inflammatory monocytes underlies the pathogenesis of atherosclerosis. However, approaches that can effectively resolve chronic low-grade inflammation targeting monocytes are not readily available. The small chemical...
3.
Prasasya R, Caldwell B, Liu Z, Wu S, Leu N, Fowler J, et al.
Dev Cell
. 2024 Apr;
59(8):1010-1027.e8.
PMID: 38569549
Ten-eleven translocation (TET) enzymes iteratively oxidize 5-methylcytosine (5mC) to generate 5-hydroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxylcytosine to facilitate active genome demethylation. Whether these bases are required to promote replication-coupled dilution or...
4.
Caldwell B, Wu Y, Wang J, Li L
Cell Rep
. 2024 Mar;
43(3):113894.
PMID: 38442017
Monocytes can develop an exhausted memory state characterized by reduced differentiation, pathogenic inflammation, and immune suppression that drives immune dysregulation during sepsis. Chromatin alterations, notably via histone modifications, underlie innate...
5.
Caldwell B, Li L
J Leukoc Biol
. 2024 Feb;
115(4):589-606.
PMID: 38301269
Innate immune cells play essential roles in modulating both immune defense and inflammation by expressing a diverse array of cytokines and inflammatory mediators, phagocytizing pathogens to promote immune clearance, and...
6.
Caldwell B, Wu Y, Wang J, Li L
bioRxiv
. 2023 Sep;
PMID: 37693554
Innate immune memory is the process by which pathogen exposure elicits cell-intrinsic states to alter the strength of future immune challenges. Such altered memory states drive monocyte dysregulation during sepsis,...
7.
Prasasya R, Caldwell B, Liu Z, Wu S, Leu N, Fowler J, et al.
bioRxiv
. 2023 Mar;
PMID: 36865267
DNA methylation erasure is required for mammalian primordial germ cell reprogramming. TET enzymes iteratively oxidize 5-methylcytosine to generate 5-hyroxymethylcytosine (5hmC), 5-formylcytosine, and 5-carboxycytosine to facilitate active genome demethylation. Whether these...
8.
Caldwell B, Bartolomei M
Andrology
. 2022 Sep;
11(5):884-890.
PMID: 36150101
The mammalian genome undergoes extensive epigenetic reprogramming twice during development, once during gestation when primordial germ cells (PGCs) are specified from somatic cells and a second time after fertilization in...
9.
Caldwell B, Liu M, Prasasya R, Wang T, DeNizio J, Leu N, et al.
Mol Cell
. 2020 Dec;
81(4):859-869.e8.
PMID: 33352108
Active DNA demethylation via ten-eleven translocation (TET) family enzymes is essential for epigenetic reprogramming in cell state transitions. TET enzymes catalyze up to three successive oxidations of 5-methylcytosine (5mC), generating...
10.
Otis J, Shen M, Caldwell B, Reyes Gaido O, Farber S
Am J Physiol Gastrointest Liver Physiol
. 2019 Jan;
316(3):G350-G365.
PMID: 30629468
Difficulty in imaging the vertebrate intestine in vivo has hindered our ability to model nutrient and protein trafficking from both the lumenal and basolateral aspects of enterocytes. Our goal was...