Bjorn Windshugel
Overview
Explore the profile of Bjorn Windshugel including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
267
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Recent Articles
1.
Kuzikov M, Morasso S, Reinshagen J, Wolf M, Monaco V, Cozzolino F, et al.
ACS Pharmacol Transl Sci
. 2025 Jan;
8(1):66-77.
PMID: 39816795
The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting...
2.
Scattolini A, Grammatoglou K, Nikitjuka A, Jirgensons A, Mansilla M, Windshugel B
ACS Infect Dis
. 2024 May;
10(6):2172-2182.
PMID: 38724014
Lipoic acid (LA) is an essential cofactor in prokaryotic and eukaryotic organisms, required for the function of several multienzyme complexes such as oxoacid dehydrogenases. Prokaryotes either synthesize LA or salvage...
3.
Kuzikov M, Reinshagen J, Wycisk K, Corona A, Esposito F, Malune P, et al.
Virus Res
. 2024 Mar;
343:199356.
PMID: 38490582
Coronaviruses contain one of the largest genomes among the RNA viruses, coding for 14-16 non-structural proteins (nsp) that are involved in proteolytic processing, genome replication and transcription, and four structural...
4.
Szal T, Chauhan S, Lewe P, Rachad F, Madre M, Paunina L, et al.
Biomolecules
. 2023 Jun;
13(6).
PMID: 37371580
Efflux pumps are a relevant factor in antimicrobial resistance. In , the tripartite efflux pump AcrAB-TolC removes a chemically diverse set of antibiotics from the bacterium. Therefore, small molecules interfering...
5.
McCabe N, Stevenson L, Scanlon E, Douglas R, Kennedy S, Keminer O, et al.
Cancers (Basel)
. 2022 Aug;
14(15).
PMID: 35954391
Drug resistance limits the effectiveness of oesophageal adenocarcinoma (OAC) chemotherapies, leading to a poor prognosis for this disease. Elucidation of the underlying resistance mechanisms is key to enabling the identification...
6.
Hirte S, Burk O, Tahir A, Schwab M, Windshugel B, Kirchmair J
Cells
. 2022 Apr;
11(8).
PMID: 35455933
The pregnane X receptor (PXR) regulates the metabolism of many xenobiotic and endobiotic substances. In consequence, PXR decreases the efficacy of many small-molecule drugs and induces drug-drug interactions. The prediction...
7.
Mandal M, Kronenberger T, Zulka M, Windshugel B, Schiermeyer A
Biotechnol J
. 2022 Jan;
17(4):e2100266.
PMID: 35075794
The production of biopharmaceuticals in engineered plant-based systems is a promising technology that has proven its suitability for the production of various recombinant glyco-proteins that are currently undergoing clinical trials....
8.
Burk O, Kronenberger T, Keminer O, Lee S, Schiergens T, Schwab M, et al.
Mol Pharmacol
. 2021 Jan;
99(3):184-196.
PMID: 33483427
The HIV protease inhibitor nelfinavir is currently being analyzed for repurposing as an anticancer drug for many different cancers because it exerts manifold off-target protein interactions, finally resulting in cancer...
9.
Chachulski L, Windshugel B
J Chem Inf Model
. 2020 Dec;
60(12):6544-6554.
PMID: 33289563
Fragment-based drug design is a popular approach in drug discovery, which makes use of computational methods such as molecular docking. To assess fragment placement performance of molecular docking programs, we...
10.
Keminer O, Teigeler M, Kohler M, Wenzel A, Arning J, Kassner F, et al.
Sci Total Environ
. 2019 Dec;
717:134743.
PMID: 31836225
Bisphenol A (BPA) is a high production volume chemical with a broad application spectrum. As an endocrine disrupting chemical, mainly by modulation of nuclear receptors (NRs), BPA has an adverse...