Bjarne Gram Hansen
Overview
Explore the profile of Bjarne Gram Hansen including associated specialties, affiliations and a list of published articles.
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Articles
15
Citations
831
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0
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Recent Articles
1.
Lund A, Kildegaard H, Petersen M, Rank J, Hansen B, Andersen M, et al.
PLoS One
. 2014 Jun;
9(5):e96693.
PMID: 24879460
A new versatile mammalian vector system for protein production, cell biology analyses, and cell factory engineering was developed. The vector system applies the ligation-free uracil-excision based technique--USER cloning--to rapidly construct...
2.
Nielsen M, Klejnstrup M, Rohlfs M, Anyaogu D, Nielsen J, Gotfredsen C, et al.
PLoS One
. 2013 Aug;
8(8):e73369.
PMID: 23991191
Secondary metabolites are known to serve a wide range of specialized functions including communication, developmental control and defense. Genome sequencing of several fungal model species revealed that the majority of...
3.
Hansen B, Mnich E, Nielsen K, Nielsen J, Nielsen M, Mortensen U, et al.
Appl Environ Microbiol
. 2012 May;
78(14):4908-13.
PMID: 22544261
Mycophenolic acid (MPA) is a fungal secondary metabolite and the active component in several immunosuppressive pharmaceuticals. The gene cluster coding for the MPA biosynthetic pathway has recently been discovered in...
4.
Mikkelsen M, Buron L, Salomonsen B, Olsen C, Hansen B, Mortensen U, et al.
Metab Eng
. 2012 Feb;
14(2):104-11.
PMID: 22326477
Epidemiological studies have shown that consumption of cruciferous vegetables, such as, broccoli and cabbages, is associated with a reduced risk of developing cancer. This phenomenon has been attributed to specific...
5.
Sun X, Hansen B, Hedstrom L
J Biol Chem
. 2011 Oct;
286(47):40595-600.
PMID: 21979957
The filamentous fungus Penicillium brevicompactum produces the immunosuppressive drug mycophenolic acid (MPA), which is a potent inhibitor of eukaryotic IMP dehydrogenases (IMPDHs). IMPDH catalyzes the conversion of IMP to XMP...
6.
Olsen L, Hansen N, Bonde M, Genee H, Holm D, Carlsen S, et al.
Nucleic Acids Res
. 2011 May;
39(Web Server issue):W61-7.
PMID: 21622660
Uracil-Specific Exision Reagent (USER) fusion is a recently developed technique that allows for assembly of multiple DNA fragments in a few simple steps. However, designing primers for USER fusion is...
7.
Regueira T, Kildegaard K, Hansen B, Mortensen U, Hertweck C, Nielsen J
Appl Environ Microbiol
. 2011 Mar;
77(9):3035-43.
PMID: 21398490
Mycophenolic acid (MPA) is the active ingredient in the increasingly important immunosuppressive pharmaceuticals CellCept (Roche) and Myfortic (Novartis). Despite the long history of MPA, the molecular basis for its biosynthesis...
8.
Mikkelsen M, Fuller V, Hansen B, Nafisi M, Olsen C, Nielsen H, et al.
Planta
. 2009 Mar;
229(6):1209-17.
PMID: 19263076
Indole-3-acetaldoxime (IAOx) is a key branching point between primary and secondary metabolism. IAOx serves as an intermediate in the biosynthesis of indole glucosinolates (I-GLSs), camalexin and the plant hormone indole-3-acetic...
9.
Li J, Hansen B, Ober J, Kliebenstein D, Halkier B
Plant Physiol
. 2008 Sep;
148(3):1721-33.
PMID: 18799661
Glucosinolates (GSLs) are amino acid-derived secondary metabolites with diverse biological activities dependent on chemical modifications of the side chain. We previously identified the flavin-monooxygenase FMO(GS-OX1) as an enzyme in the...
10.
Rowe H, Hansen B, Halkier B, Kliebenstein D
Plant Cell
. 2008 Jun;
20(5):1199-216.
PMID: 18515501
Genomic approaches have accelerated the study of the quantitative genetics that underlie phenotypic variation. These approaches associate genome-scale analyses such as transcript profiling with targeted phenotypes such as measurements of...