Binhan Yu
Overview
Explore the profile of Binhan Yu including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
200
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Recent Articles
1.
Wang X, Yu B, Wang T, Iwahara J
J Phys Chem Lett
. 2025 Feb;
16(9):2175-2180.
PMID: 39980265
Although nuclear magnetic resonance (NMR) spectroscopy is powerful for protein dynamics investigations, the anisotropy of internal motions has been difficult to analyze with NMR. In principle, NMR order parameters for...
2.
Yu B, Bolik-Coulon N, Rangadurai A, Kay L, Iwahara J
J Am Chem Soc
. 2024 Jul;
146(30):20788-20801.
PMID: 39028837
NMR spectroscopy is an important tool for the measurement of the electrostatic properties of biomolecules. To this point, paramagnetic relaxation enhancements (PREs) of H nuclei arising from nitroxide cosolutes in...
3.
Wang X, Holthauzen L, Paz-Villatoro J, Bien K, Yu B, Iwahara J
Biochemistry
. 2024 Jun;
63(14):1718-1722.
PMID: 38916994
The HMGB1 protein typically serves as a DNA chaperone that assists DNA-repair enzymes and transcription factors but can translocate from the nucleus to the cytoplasm or even to extracellular space...
4.
Yu B, Wang X, Tan K, Iwahara J
J Am Chem Soc
. 2024 May;
146(22):14922-14926.
PMID: 38771003
Many human proteins possess intrinsically disordered regions containing consecutive aspartate or glutamate residues ("D/E repeats"). Approximately half of them are DNA/RNA-binding proteins. In this study, using nuclear magnetic resonance (NMR)...
5.
Wang X, Yu B, Sakurabayashi S, Paz-Villatoro J, Iwahara J
J Am Chem Soc
. 2024 Jan;
146(3):1748-1752.
PMID: 38191993
Single-stranded DNA (ssDNA) oligonucleotides are widely used in biological research, therapeutics, biotechnology, and nanomachines. Large-scale enzymatic production of ssDNA oligonucleotides forming noncanonical structures has been difficult. Here, we present a...
6.
Iwahara J, Pettitt B, Yu B
Curr Opin Struct Biol
. 2023 Aug;
82:102680.
PMID: 37573815
Biomolecular electrostatics has been a subject of computational investigations based on 3D structures. This situation is changing because emerging experimental tools allow us to quantitatively investigate biomolecular electrostatics without any...
7.
Yu B, Iwahara J
Biopolymers
. 2023 May;
115(2):e23553.
PMID: 37254885
Before reaching their targets, sequence-specific DNA-binding proteins nonspecifically bind to DNA through electrostatic interactions and stochastically change their locations on DNA. Investigations into the dynamics of DNA-scanning by proteins are...
8.
Wang X, Bigman L, Greenblatt H, Yu B, Levy Y, Iwahara J
Nucleic Acids Res
. 2023 Feb;
51(10):4701-4712.
PMID: 36774964
In eukaryotes, many DNA/RNA-binding proteins possess intrinsically disordered regions (IDRs) with large negative charge, some of which involve a consecutive sequence of aspartate (D) or glutamate (E) residues. We refer...
9.
Yu B, Wang X, Wang T, Iwahara J
Methods
. 2023 Jan;
210:1-9.
PMID: 36596431
Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool used to investigate the dynamic properties of biological macromolecules and their complexes. NMR relaxation data can provide order parameters S, which...
10.
Yu B, Wang X, Iwahara J
J Phys Chem Lett
. 2022 Oct;
13(42):10025-10029.
PMID: 36264151
Electrostatic potentials around macromolecules in the presence of mobile charges are difficult to assess especially for highly charged systems. Here, we report measurements of local electrostatic potentials around DNA by...