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» Authors » Bianca Seigel

Bianca Seigel

Explore the profile of Bianca Seigel including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 560
Followers 0
Related Specialties
Microbiology
Gastroenterology
Allergy & Immunology
Top 10 Co-Authors
Hubert E Blum
Robert Thimme
Bertram Bengsch
Eva Billerbeck
Volker Lohmann
Chris B Willberg
Ye H Oo
Lucy Walker
Paul Klenerman
David H Adams
Published In
J Gen Virol
J Hepatol
Front Immunol
Proc Natl Acad Sci U S A
J Immunol
Affiliations
Soon will be listed here.
Recent Articles
1.
CD161(+)CD4(+) T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and IFN-γ
Kang Y, Seigel B, Bengsch B, Fleming V, Billerbeck E, Simmons R, et al.
Front Immunol . 2012 Nov; 3:346. PMID: 23181064
Hepatitis C virus infection is a major cause of chronic liver disease. CD4(+) T cells play a key role in disease outcome. However, the critical functions and associated phenotypes of...
2.
Factors that determine the antiviral efficacy of HCV-specific CD8(+) T cells ex vivo
Seigel B, Bengsch B, Lohmann V, Bartenschlager R, Blum H, Thimme R
Gastroenterology . 2012 Nov; 144(2):426-436. PMID: 23142136
Background & Aims: Dysfunctional CD8(+) T cells are believed to contribute to the ability of hepatitis C virus (HCV) to evade the immune response. Most studies have focused on the...
3.
Human Th17 cells express high levels of enzymatically active dipeptidylpeptidase IV (CD26)
Bengsch B, Seigel B, Flecken T, Wolanski J, Blum H, Thimme R
J Immunol . 2012 Apr; 188(11):5438-47. PMID: 22539793
Dipeptidylpeptidase IV (CD26) is a multifunctional ectoenzyme involved in T cell activation that has been implicated in autoimmune pathophysiology. Because IL-17-producing CD4(+) T cells (Th17 cells) are important mediators of...
4.
Low perforin expression of early differentiated HCV-specific CD8+ T cells limits their hepatotoxic potential
Jo J, Bengsch B, Seigel B, Rau S, Schmidt J, Bisse E, et al.
J Hepatol . 2012 Mar; 57(1):9-16. PMID: 22425625
Background & Aims: Perforin plays a central role in the immunopathogenesis of different viral infections. However, its role in hepatitis C virus (HCV) infection has not been fully understood. Here,...
5.
Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation
Bengsch B, Seigel B, Ruhl M, Timm J, Kuntz M, Blum H, et al.
PLoS Pathog . 2010 Jun; 6(6):e1000947. PMID: 20548953
Exhausted CD8+ T cell responses during chronic viral infections are defined by a complex expression pattern of inhibitory receptors. However, very little information is currently available about the coexpression patterns...
6.
Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties
Billerbeck E, Kang Y, Walker L, Lockstone H, Grafmueller S, Fleming V, et al.
Proc Natl Acad Sci U S A . 2010 Feb; 107(7):3006-11. PMID: 20133607
CD8(+) T lymphocytes play a key role in host defense, in particular against important persistent viruses, although the critical functional properties of such cells in tissue are not fully defined....
7.
Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection
Billerbeck E, Nakamoto N, Seigel B, Blum H, Chang K, Thimme R
J Gen Virol . 2009 Mar; 90(Pt 7):1692-1701. PMID: 19321758
It has been shown previously that suppressive virus-specific FoxP3+ regulatory CD8+ T cells can be expanded from human peripheral blood mononuclear cells after in vitro antigen-specific stimulation. This study extended...