Bettina Lieske
Overview
Explore the profile of Bettina Lieske including associated specialties, affiliations and a list of published articles.
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24
Citations
146
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0
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Recent Articles
1.
Li Z, Zhang B, Chan J, Tabatabaeian H, Tong Q, Chew X, et al.
Cell Genom
. 2024 Aug;
4(9):100641.
PMID: 39216476
Colorectal cancer (CRC) ranks as the second leading cause of cancer deaths globally. In recent years, short-read single-cell RNA sequencing (scRNA-seq) has been instrumental in deciphering tumor heterogeneities. However, these...
2.
Lau J, Choe L, Hui Juan Lee D, Khoo A, Koh W, Peh C, et al.
J Natl Compr Canc Netw
. 2024 Jul;
22(6).
PMID: 39074504
Background: Colorectal cancer (CRC) is one of the few cancers for which screening has been associated with better survival and morbidity, but screening uptake has been underexplored in spouses of...
3.
Ren Y, Manoharan T, Liu B, Ming Cheng C, Siew B, Cheong W, et al.
J Immunother Cancer
. 2024 Mar;
12(3).
PMID: 38508656
Background: The effectiveness of somatic neoantigen-based immunotherapy is often hindered by the limited number of mutations in tumors with low to moderate mutation burden. Focusing on microsatellite-stable colorectal cancer (CRC),...
4.
Thng D, Hooi L, Siew B, Lee K, Tan I, Lieske B, et al.
NPJ Precis Oncol
. 2024 Feb;
8(1):52.
PMID: 38413740
Globally, colorectal cancer (CRC) is the third most frequently occurring cancer. Progression on to an advanced metastatic malignancy (metCRC) is often indicative of poor prognosis, as the 5-year survival rates...
5.
Law J, Lau J, Pang N, Khoo A, Cheong W, Lieske B, et al.
Medicina (Kaunas)
. 2023 Jun;
59(6).
PMID: 37374333
: It remains unclear which domains of preoperative health-related quality of life (HRQOL) and mental health are predictive of postoperative clinical and patient-reported outcomes in colorectal cancer (CRC) patients. A...
6.
Ho T, Lee M, Goh H, Ng G, Lee J, Kannan S, et al.
Nat Commun
. 2023 Mar;
14(1):1726.
PMID: 36977662
Mis-sense mutations affecting TP53 promote carcinogenesis both by inactivating tumor suppression, and by conferring pro-carcinogenic activities. We report here that p53 DNA-binding domain (DBD) and transactivation domain (TAD) mis-sense mutants...
7.
Chan J, Zhang B, Chew X, Salhi A, Kwok Z, Lim C, et al.
Nat Cell Biol
. 2022 May;
24(6):928-939.
PMID: 35618746
Most mammalian genes generate messenger RNAs with variable untranslated regions (UTRs) that are important post-transcriptional regulators. In cancer, shortening at 3' UTR ends via alternative polyadenylation can activate oncogenes. However,...
8.
Desi N, Teh V, Tong Q, Lim C, Tabatabaeian H, Chew X, et al.
Oncogene
. 2021 Dec;
41(8):1178-1189.
PMID: 34937878
3'UTR shortening in cancer has been shown to activate oncogenes, partly through the loss of microRNA-mediated repression. This suggests that many reported microRNA-oncogene target interactions may not be present in...
9.
Lim T, Tham H, Yaow C, Tan I, Chan D, Farouk R, et al.
Surg Endosc
. 2021 Jan;
35(12):7120-7130.
PMID: 33433675
Background: Placement of self-expanding metal stents has been increasingly adopted as a bridge to surgery in patients presenting with obstructed left-sided colorectal cancers. The optimal bridging time has yet to...
10.
Kim G, Tan H, Sundar R, Lieske B, Chee C, Ho J, et al.
Clin Cancer Res
. 2020 Nov;
27(7):1875-1881.
PMID: 33148667
Purpose: Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel laparoscopic, intraperitoneal chemotherapy delivery technique aiming to improve drug distribution and tissue penetration to treat peritoneal metastases. Thus far, PIPAC oxaliplatin...