Bethlyn Sloey
Overview
Explore the profile of Bethlyn Sloey including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
47
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0
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Recent Articles
1.
Kroenke M, Weeraratne D, Deng H, Sloey B, Subramanian R, Wu B, et al.
J Immunol Methods
. 2017 Mar;
445:37-44.
PMID: 28274835
The immunogenicity risk assessment and bioanalytical strategy for novel therapeutics should account for both unique biophysical properties and potential consequences of immunogenicity. When assessing the immunogenicity risk of etelcalcetide, a...
2.
Andrews D, Hamadeh H, He Y, Boren B, Turk J, Boyce R, et al.
Toxicol Pathol
. 2013 May;
42(3):540-54.
PMID: 23674392
We previously reported an increased incidence of thrombotic toxicities in Sprague-Dawley rats administered the highest dose level of a hyperglycosylated analog of recombinant human erythropoietin (AMG 114) for 1 month...
3.
Andrews D, Boren B, Turk J, Boyce R, He Y, Hamadeh H, et al.
Toxicol Pathol
. 2013 May;
42(3):524-39.
PMID: 23674391
We recently reported results that erythropoiesis-stimulating agent (ESA)-related thrombotic toxicities in preclinical species were not solely dependent on a high hematocrit (HCT) but also associated with increased ESA dose level,...
4.
Krzyzanski W, Sutjandra L, Perez-Ruixo J, Sloey B, Chow A, Wang Y
Pharm Res
. 2012 Dec;
30(3):655-69.
PMID: 23250851
Purpose: Romiplostim is a novel thrombopoiesis-stimulating peptibody that targets the thrombopoietin c-Mpl receptor, resulting in increased platelet production. The pharmacodynamic-mediated disposition (PDMDD) and its stimulatory effect on platelet production in...
5.
Wang Y, Sloey B, Wong T, Khandelwal P, Melara R, Sun Y
Pharm Res
. 2011 Apr;
28(8):1931-8.
PMID: 21476045
Purpose: Romiplostim, a treatment for adults with immune thrombocytopenia (ITP), is a novel thrombopoietin mimetic agent with a similar mechanism of action as thrombopoietin with no sequence homology. Structurally, it...
6.
Thway T, Ma M, Lee J, Sloey B, Yu S, Wang Y, et al.
J Pharm Biomed Anal
. 2009 Jan;
49(3):613-8.
PMID: 19150189
A case study of experimental and statistical approaches for cross-validating and examining the equivalence of two ligand binding assay (LBA) methods that were employed in pharmacokinetic (PK) studies is presented....