Bertram Klinger
Overview
Explore the profile of Bertram Klinger including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
819
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Recent Articles
1.
Klinger B, Rausch I, Sieber A, Kutz H, Kruse V, Kirchner M, et al.
PLoS Comput Biol
. 2024 Oct;
20(10):e1012488.
PMID: 39352924
B cell receptor (BCR) signaling is required for the survival and maturation of B cells and is deregulated in B cell lymphomas. While proximal BCR signaling is well studied, little...
2.
Zschaeck S, Klinger B, van den Hoff J, Cegla P, Apostolova I, Kreissl M, et al.
Sci Rep
. 2023 Nov;
13(1):20840.
PMID: 38012155
One important aim of precision oncology is a personalized treatment of patients. This can be achieved by various biomarkers, especially imaging parameters and gene expression signatures are commonly used. So...
3.
Sultana Z, Dorel M, Klinger B, Sieber A, Dunkel I, Bluthgen N, et al.
Mol Syst Biol
. 2023 Sep;
19(11):e11510.
PMID: 37735975
For a short period during early development of mammalian embryos, both X chromosomes in females are active, before dosage compensation is ensured through X-chromosome inactivation. In female mouse embryonic stem...
4.
Schoetz U, Klein D, Hess J, Shnayien S, Spoerl S, Orth M, et al.
Cell Death Dis
. 2021 Dec;
12(12):1162.
PMID: 34911941
Resistance against radio(chemo)therapy-induced cell death is a major determinant of oncological treatment failure and remains a perpetual clinical challenge. The underlying mechanisms are manifold and demand for comprehensive, cancer entity-...
5.
Dorel M, Klinger B, Mari T, Toedling J, Blanc E, Messerschmidt C, et al.
PLoS Comput Biol
. 2021 Nov;
17(11):e1009515.
PMID: 34735429
Very high risk neuroblastoma is characterised by increased MAPK signalling, and targeting MAPK signalling is a promising therapeutic strategy. We used a deeply characterised panel of neuroblastoma cell lines and...
6.
Kuhn N, Klinger B, Uhlitz F, Sieber A, Rivera M, Klotz-Noack K, et al.
Adv Biol Regul
. 2021 Jan;
79:100778.
PMID: 33431353
In colorectal cancer (CRC), the prevalence of NRAS mutations (5-9%) is inferior to that of KRAS mutations (40-50%). NRAS mutations feature lately during tumour progression and drive resistance to anti-EGFR...
7.
Denkena J, Zaisser A, Merz B, Klinger B, Kuhl D, Bluthgen N, et al.
Mol Brain
. 2020 Nov;
13(1):148.
PMID: 33172478
Neuronal activity-regulated gene transcription underlies plasticity-dependent changes in the molecular composition and structure of neurons. A large number of genes regulated by different neuronal plasticity inducing pathways have been identified,...
8.
Klotz-Noack K, Klinger B, Rivera M, Bublitz N, Uhlitz F, Riemer P, et al.
Cell Rep
. 2020 Sep;
32(12):108184.
PMID: 32966782
Oncoproteins such as the BRAF kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities. Targeting of BRAF-driven cytoplasmic signaling networks has proved ineffective, as patients regularly...
9.
Gastl B, Klotz-Noack K, Klinger B, Ispasanie S, Salib K, Zuber J, et al.
Cell Death Dis
. 2020 Jul;
11(7):499.
PMID: 32612138
To unravel vulnerabilities of KRAS-mutant CRC cells, a shRNA-based screen specifically inhibiting MAPK pathway components and targets was performed in CaCo2 cells harboring conditional oncogenic KRAS. The custom-designed shRNA library...
10.
Rydenfelt M, Klinger B, Klunemann M, Bluthgen N
Nucleic Acids Res
. 2020 Apr;
48(W1):W307-W312.
PMID: 32313938
Extracting signalling pathway activities from transcriptome data is important to infer mechanistic origins of transcriptomic dysregulation, for example in disease. A popular method to do so is by enrichment analysis...