Bert A t Hart
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Explore the profile of Bert A t Hart including associated specialties, affiliations and a list of published articles.
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116
Citations
2468
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Recent Articles
1.
Stys P, Tsutsui S, Gafson A, t Hart B, Belachew S, Geurts J
Front Cell Neurosci
. 2024 Aug;
18:1426231.
PMID: 39161786
Multiple sclerosis (MS) is a frequently disabling neurological disorder characterized by symptoms, clinical signs and imaging abnormalities that typically fluctuate over time, affecting any level of the CNS. Prominent lymphocytic...
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Luchicchi A, Munoz-Gonzalez G, Halperin S, Strijbis E, van Dijk L, Foutiadou C, et al.
Ann Clin Transl Neurol
. 2024 Mar;
11(4):973-988.
PMID: 38425098
Objective: Multiple sclerosis (MS) is a chronic central nervous system disease whose white matter lesion origin remains debated. Recently, we reported subtle changes in the MS normal appearing white matter...
4.
Licht-Mayer S, Campbell G, Mehta A, McGill K, Symonds A, Al-Azki S, et al.
Neuropathol Appl Neurobiol
. 2022 Oct;
49(1):e12851.
PMID: 36181265
Aims: Axonal injury in multiple sclerosis (MS) and experimental models is most frequently detected in acutely demyelinating lesions. We recently reported a compensatory neuronal response, where mitochondria move to the...
5.
Halperin S, t Hart B, Luchicchi A, Schenk G
Biomedicines
. 2022 Mar;
10(3).
PMID: 35327408
Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system (CNS), traditionally considered a chronic autoimmune attack against the insulating myelin sheaths around axons. However, the exact etiology...
6.
Perez-Munoz M, Sugden S, Harmsen H, t Hart B, Laman J, Walter J
iScience
. 2021 Jul;
24(7):102709.
PMID: 34296070
Studies in experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis, have shown potential links between diet components, microbiome composition, and modulation of immune responses. In this review, we...
7.
t Hart B, Luchicchi A, Schenk G, Stys P, Geurts J
Ann Clin Transl Neurol
. 2021 Jun;
8(8):1709-1719.
PMID: 34156169
The neuroinflammatory disease multiple sclerosis is driven by autoimmune pathology in the central nervous system. However, the trigger of the autoimmune pathogenic process is unknown. MS models in immunologically naïve,...
8.
t Hart B, Luchicchi A, Schenk G, Killestein J, Geurts J
EBioMedicine
. 2021 May;
68:103392.
PMID: 34044219
Multiple sclerosis (MS) is after trauma the most important neurological disease in young adults, affecting 1 per 1000 individuals. With currently available medications, most of these targeting the immune system,...
9.
Ten Bosch G, Bolk J, t Hart B, Laman J
J Mol Med (Berl)
. 2021 May;
99(8):1033-1042.
PMID: 33948692
Reassessment of published observations in patients with multiple sclerosis (MS) suggests a microglial malfunction due to inappropriate (over)activity of the mitogen-activated protein kinase pathway ERK (MAPK). These observations regard biochemistry...
10.
Laman J, t Hart B, Power C, Dziarski R
Trends Mol Med
. 2020 Jun;
26(7):670-682.
PMID: 32589935
Peptidoglycan (PGN) is a cell wall component of both Gram-positive and Gram-negative bacteria. Signature fragments of PGN are proinflammatory through engagement of pattern recognition receptors (PRR) on resident tissue cells...